ST8SIA6

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 is a protein that in humans is encoded by the ST8SIA6 gene. ^[5]

ST8SIA6
Identifiers
Aliases	ST8SIA6, SIA8F, SIAT8F, ST8SIA-VI, ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6, ST8SiaVI, SIAT8-F
External IDs	OMIM: 610139; MGI: 2386797; HomoloGene: 17112; GeneCards: ST8SIA6; OMA:ST8SIA6 - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10p12.33 Start 17,315,421 bp[1] End 17,454,595 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 A1 Start 13,655,832 bp[2] End 13,798,875 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle gonad substantia nigra apex of heart left ventricle right auricle of heart epithelium of colon lung thymus white blood cell Top expressed in conjunctival fornix transitional epithelium of urinary bladder substantia nigra epithelium of stomach hair follicle cornea lateral septal nucleus lacrimal gland ciliary body lumbar subsegment of spinal cord More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity sialyltransferase activity glycosyltransferase activity alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity Cellular component integral component of membrane Golgi membrane Golgi apparatus membrane Biological process glycolipid biosynthetic process sialylation protein glycosylation protein O-linked glycosylation glycoprotein metabolic process oligosaccharide metabolic process ganglioside biosynthetic process carbohydrate biosynthetic process blastocyst hatching Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 338596 241230 Ensembl ENSG00000148488 ENSMUSG00000003418 UniProt P61647 Q8K4T1 RefSeq (mRNA) NM_001004470 NM_001345961 NM_145838 RefSeq (protein) NP_001004470 NP_001332890 NP_665837 Location (UCSC) Chr 10: 17.32 – 17.45 Mb Chr 2: 13.66 – 13.8 Mb PubMed search [3] [4]
Wikidata
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Function

Sialic acid is a key determinate of oligosaccharide structures involved in cell-cell communication, cell-substrate interaction, adhesion, and protein targeting. ST8SIA6 belongs to a family of sialyltransferases (EC 2.4.99.8) that synthesize sialylglycoconjugates (Takashima et al., 2002 [PubMed 11980897]).