STAB2

Stabilin-2 is a protein that in humans is encoded by the STAB2 gene.^[5][6][7]

STAB2
Identifiers
Aliases	STAB2, FEEL2, FELE-2, FELL2, FEX2, HARE, SCARH1, stabilin 2
External IDs	OMIM: 608561; MGI: 2178743; HomoloGene: 23022; GeneCards: STAB2; OMA:STAB2 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q23.3 Start 103,587,273 bp[1] End 103,766,719 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 C1 Start 86,841,198 bp[2] End 87,008,025 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in spleen right lobe of liver testicle muscle layer of sigmoid colon sperm lymph node oocyte superficial temporal artery popliteal artery tibial arteries Top expressed in mesenteric lymph nodes spleen left lobe of liver yolk sac muscle of thigh knee joint female urethra triceps brachii muscle gastrocnemius muscle tibiofemoral joint More reference expression data BioGPS n/a
Gene ontology Molecular function low-density lipoprotein particle receptor activity protein-disulfide reductase activity low-density lipoprotein particle binding scavenger receptor activity protein binding hyaluronic acid binding calcium ion binding Cellular component integral component of membrane endocytic vesicle membrane membrane plasma membrane integral component of plasma membrane external side of plasma membrane cytoplasm cytosol Biological process endocytosis hyaluronan catabolic process receptor-mediated endocytosis cell adhesion defense response to bacterium angiogenesis defense response to Gram-positive bacterium Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55576 192188 Ensembl ENSG00000136011 ENSMUSG00000035459 UniProt Q8WWQ8 Q8R4U0 RefSeq (mRNA) NM_017564 NM_138673 RefSeq (protein) NP_060034 NP_619614 Location (UCSC) Chr 12: 103.59 – 103.77 Mb Chr 10: 86.84 – 87.01 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a large, transmembrane receptor protein which may function in angiogenesis, lymphocyte homing, cell adhesion, or receptor scavenging. The protein contains 7 fasciclin, 15 epidermal growth factor (EGF)-like, and 2 laminin-type EGF-like domains as well as a C-type lectin-like hyaluronan-binding Link module. The protein is primarily expressed on liver sinusoidal endothelial cells, spleen, and lymph node. The receptor has been shown to bind and endocytose ligands such as hyaluronan, low density lipoprotein, Gram-positive and Gram-negative bacteria, and advanced glycosylation end products. Supporting its possible role as a scavenger receptor, the protein has been shown to cycle between the plasma membrane and lysosomes.^[7]