STARD10

StAR-related lipid transfer protein 10 (STARD10) or PCTP-like protein is a lipid transfer protein that in humans is encoded by the STARD10 gene.^[5][6] The protein derives its name from the fact that the molecule contains a START domain. As part of the StarD2 subfamily, StarD10 can transport the lipids phosphatidylcholine and phosphatidylethanolamine between membranes in solution.^[7] Casein kinase II phosphorylates the protein on its serine at position 184.^[8]

STARD10
Identifiers
Aliases	STARD10, NY-CO-28, PCTP2, SDCCAG28, CGI-52, StAR related lipid transfer domain containing 10
External IDs	OMIM: 617382; MGI: 1860093; HomoloGene: 4841; GeneCards: STARD10; OMA:STARD10 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q13.4 Start 72,754,729 bp[1] End 72,794,047 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 E2 Start 100,966,293 bp[2] End 100,995,833 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver mucosa of transverse colon body of pancreas left adrenal cortex right testis left testis right adrenal cortex rectum olfactory zone of nasal mucosa mucosa of ileum Top expressed in left lobe of liver epithelium of stomach pyloric antrum crypt of lieberkuhn of small intestine seminiferous tubule gallbladder mucous cell of stomach right kidney spermatid human kidney More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding lipid binding phospholipid transporter activity Cellular component cytoplasm cell projection cytosol microvillus membrane intercellular canaliculus motile cilium cilium Biological process bile acid secretion positive regulation of peroxisome proliferator activated receptor signaling pathway lipid transport phosphatidylcholine biosynthetic process phospholipid transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10809 56018 Ensembl ENSG00000214530 ENSMUSG00000030688 UniProt Q9Y365 Q9JMD3 RefSeq (mRNA) NM_006645 NM_019990 NM_001360460 RefSeq (protein) NP_006636 NP_064374 NP_001347389 Location (UCSC) Chr 11: 72.75 – 72.79 Mb Chr 7: 100.97 – 101 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

The function of StarD10 in the cell is not yet understood. Its expression is associated with cancer, but the nature of its role is unclear. Most recent data indicate that loss of StarD10 expression in breast cancer is associated with poor outcomes in patients.^[9]