STARD8

StAR-related lipid transfer domain protein 8 (STARD8) also known as deleted in liver cancer 3 protein (DLC-3) is a protein that in humans is encoded by the STARD8 gene^[5][6] and is a member of the DLC family.

STARD8
Identifiers
Aliases	STARD8, ARHGAP38, DLC3, STARTGAP3, StAR related lipid transfer domain containing 8
External IDs	OMIM: 300689; MGI: 2448556; HomoloGene: 22837; GeneCards: STARD8; OMA:STARD8 - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xq13.1 Start 68,647,666 bp[1] End 68,725,842 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X|X C3 Start 98,046,854 bp[2] End 98,118,334 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lung upper lobe of left lung apex of heart olfactory bulb human kidney testicle left ventricle right lobe of thyroid gland left uterine tube left lobe of thyroid gland Top expressed in stroma of bone marrow yolk sac right lung lobe sciatic nerve left lung extraocular muscle dermis left lung lobe myocardium of ventricle human kidney More reference expression data BioGPS n/a
Gene ontology Molecular function lipid binding GTPase activator activity Cellular component cytosol cell junction focal adhesion Biological process positive regulation of GTPase activity regulation of small GTPase mediated signal transduction signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9754 236920 Ensembl ENSG00000130052 ENSMUSG00000031216 UniProt Q92502 Q8K031 RefSeq (mRNA) NM_001142503 NM_001142504 NM_014725 NM_199018 RefSeq (protein) NP_001135975 NP_001135976 NP_055540 NP_950183 Location (UCSC) Chr X: 68.65 – 68.73 Mb Chr X: 98.05 – 98.12 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Structure and function

The protein is 1103 amino acids long, which like other DLC proteins consists of a sterile alpha motif (SAM), RhoGAP and a StAR-related lipid-transfer (START) domains.^[7]

The protein is a Rho GTPase-activating protein (GAP), a type of protein that regulates members of the Rho family of GTPases. STARD8 is characterized as activating Rho GTPases. Its expression inhibits the growth of human breast and prostate cancer cells in culture.^[7]

Tissue distribution and pathology

The protein is expressed in tissues throughout the body, but is absent or reduced in many kinds of tumor cells.^[7]

While there are no known disorders caused by STARD8, partial loss of the STARD8 gene occurs in cases of craniofrontonasal syndrome where the EFNB1 gene (which causes the syndrome) is completely deleted.^[8][9]