STAR (gene)

Steroidogenic acute regulatory protein is a protein that in humans is encoded by the STAR gene. ^[5]

STAR
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3P0L
Identifiers
Aliases	STAR, STARD1, steroidogenic acute regulatory protein
External IDs	OMIM: 600617; MGI: 102760; HomoloGene: 297; GeneCards: STAR; OMA:STAR - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8p11.23 Start 38,142,700 bp[1] End 38,150,992 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 A2|8 14.17 cM Start 26,296,583 bp[2] End 26,306,010 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right adrenal gland right adrenal cortex left adrenal gland left adrenal cortex left ovary right ovary right testis left testis testicle left uterine tube Top expressed in adrenal gland Gonadal ridge placenta spermatocyte testicle decidua adrenal medulla aortic valve spleen ascending aorta More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding cholesterol transfer activity lipid binding cholesterol binding Cellular component cytosol mitochondrial intermembrane space soma mitochondrial crista neuron projection mitochondrion Biological process negative regulation of neuron apoptotic process cellular response to transforming growth factor beta stimulus estrogen biosynthetic process response to ionizing radiation response to fungicide cellular response to gonadotropin stimulus phenol-containing compound metabolic process male gonad development phthalate metabolic process biphenyl metabolic process cellular response to luteinizing hormone stimulus cellular response to growth hormone stimulus lipid transport cellular lipid metabolic process response to organic cyclic compound cellular response to follicle-stimulating hormone stimulus circadian sleep/wake cycle, REM sleep response to nutrient insecticide metabolic process glucocorticoid metabolic process diterpenoid metabolic process response to corticosterone response to antibiotic response to steroid hormone cellular response to organic cyclic compound response to nicotine regulation of steroid biosynthetic process response to peptide hormone cholesterol metabolic process cellular response to alkaloid cellular response to cadmium ion cellular response to fibroblast growth factor stimulus response to activity response to organic substance response to gonadotropin cellular response to dexamethasone stimulus response to estrogen cellular response to epinephrine stimulus C21-steroid hormone biosynthetic process positive regulation of neurogenesis brain development positive regulation of gene expression cellular response to metal ion intracellular cholesterol transport response to nutrient levels response to lead ion dibenzo-p-dioxin metabolic process circadian rhythm cellular response to interferon-alpha cellular response to insulin stimulus cellular response to interferon-gamma cellular response to antibiotic regulation of neuronal synaptic plasticity response to insecticide response to ethanol response to leptin bile acid biosynthetic process cellular response to lipopolysaccharide response to toxic substance response to herbicide response to hydrogen peroxide testosterone biosynthetic process cellular response to cAMP cellular response to glucose stimulus steroid biosynthetic process organic acid metabolic process positive regulation of bile acid biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6770 20845 Ensembl ENSG00000147465 ENSMUSG00000031574 UniProt P49675 P51557 RefSeq (mRNA) NM_000349 NM_001007243 NM_011485 RefSeq (protein) NP_000340 NP_035615 Location (UCSC) Chr 8: 38.14 – 38.15 Mb Chr 8: 26.3 – 26.31 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene plays a key role in the acute regulation of steroid hormone synthesis by enhancing the conversion of cholesterol into pregnenolone. This protein permits the cleavage of cholesterol into pregnenolone by mediating the transport of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane. Mutations in this gene are a cause of congenital lipoid adrenal hyperplasia (CLAH), also called lipoid CAH. A pseudogene of this gene is located on chromosome 13. [provided by RefSeq, Jul 2008].