STEAP1

Metalloreductase STEAP1 is an enzyme that in humans is encoded by the STEAP1 gene.^[5]

STEAP1
Identifiers
Aliases	STEAP1, PRSS24, STEAP, six transmembrane epithelial antigen of the prostate 1, STEAP family member 1
External IDs	OMIM: 604415; MGI: 1917608; HomoloGene: 8256; GeneCards: STEAP1; OMA:STEAP1 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q21.13 Start 90,154,456 bp[1] End 90,164,829 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 A1|5 3.2 cM Start 5,786,317 bp[2] End 5,799,326 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pericardium cartilage tissue prostate tendon of biceps brachii Achilles tendon parietal pleura gonad mucosa of transverse colon abdominal fat gallbladder Top expressed in Epithelium of choroid plexus endothelial cell of lymphatic vessel lumbar spinal ganglion epithelium of lens molar hair follicle yolk sac adrenal gland Paneth cell iris More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ferric-chelate reductase (NADPH) activity metal ion binding transporter activity oxidoreductase activity cupric reductase activity channel activity Cellular component endosome membrane integral component of membrane cell-cell junction integral component of plasma membrane membrane endosome plasma membrane Biological process ion transport copper ion import iron ion homeostasis transmembrane transport iron ion import across cell outer membrane Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26872 70358 Ensembl ENSG00000164647 ENSMUSG00000015652 UniProt Q9UHE8 Q9CWR7 RefSeq (mRNA) NM_012449 NM_027399 RefSeq (protein) NP_036581 NP_081675 Location (UCSC) Chr 7: 90.15 – 90.16 Mb Chr 5: 5.79 – 5.8 Mb PubMed search [3] [4]
Wikidata
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This gene is predominantly expressed in prostate tissue, and is found to be upregulated in multiple cancer cell lines.^[6] The gene product is predicted to be a six-transmembrane protein, and was shown to be a cell surface antigen significantly expressed at cell-cell junctions.^[5]