STEAP2

Metalloreductase STEAP2 is an enzyme that in humans is encoded by the STEAP2 gene.^[5][6][7]

STEAP2
Identifiers
Aliases	STEAP2, IPCA1, PCANAP1, PUMPCn, STAMP1, STMP, STEAP2 metalloreductase
External IDs	OMIM: 605094; MGI: 1921301; HomoloGene: 17682; GeneCards: STEAP2; OMA:STEAP2 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q21.13 Start 90,167,590 bp[1] End 90,238,137 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 A1 Start 5,714,829 bp[2] End 5,744,578 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pericardium Achilles tendon prostate cardiac muscle tissue of right atrium Brodmann area 23 middle temporal gyrus pancreatic epithelial cell cerebellar vermis superior frontal gyrus cartilage tissue Top expressed in Epithelium of choroid plexus endothelial cell of lymphatic vessel oocyte primary oocyte secondary oocyte lumbar subsegment of spinal cord deep cerebellar nuclei lobe of cerebellum human kidney olfactory epithelium More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transporter activity metal ion binding cupric reductase activity ferric-chelate reductase (NADPH) activity oxidoreductase activity Cellular component integral component of membrane integral component of Golgi membrane cytosol endosome membrane plasma membrane early endosome trans-Golgi network transport vesicle endosome membrane integral component of plasma membrane Biological process endocytosis iron ion homeostasis copper ion import ion transport response to hormone regulated exocytosis Golgi to plasma membrane transport iron ion import across cell outer membrane Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 261729 74051 Ensembl ENSG00000157214 ENSMUSG00000015653 UniProt Q8NFT2 Q8BWB6 RefSeq (mRNA) NM_001040665 NM_001040666 NM_001244944 NM_001244945 NM_001244946 NM_152999 NM_001103156 NM_001103157 NM_001285469 NM_001285470 NM_001285471 NM_028734 RefSeq (protein) NP_001035755 NP_001035756 NP_001231873 NP_001231874 NP_001231875 NP_694544 NP_001096626 NP_001096627 NP_001272398 NP_001272399 NP_001272400 NP_083010 Location (UCSC) Chr 7: 90.17 – 90.24 Mb Chr 5: 5.71 – 5.74 Mb PubMed search [3] [4]
Wikidata
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This gene is a member of the STEAP family and encodes a multi-pass membrane protein that localizes to the Golgi complex, the plasma membrane, and the vesicular tubular structures in the cytosol.

A highly similar protein in mouse has both ferri reductase and cupric reductase activity, and stimulates the cellular uptake of both iron and copper in vitro. Increased transcriptional expression of the human gene is associated with prostate cancer progression. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.^[7]