STEAP3

Metalloreductase STEAP3 is an enzyme that in humans is encoded by the STEAP3 gene.^[5][6]

STEAP3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2VNS, 2VQ3
Identifiers
Aliases	STEAP3, AHMIO2, STMP3, TSAP6, dudlin-2, dudulin-2, pHyde, STEAP3 metalloreductase
External IDs	OMIM: 609671; MGI: 1915678; HomoloGene: 10084; GeneCards: STEAP3; OMA:STEAP3 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q14.2 Start 119,223,831 bp[1] End 119,265,652 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 E2.3 Start 120,118,487 bp[2] End 120,200,435 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver spinal ganglia olfactory zone of nasal mucosa epithelium of bronchus bronchial epithelial cell lactiferous duct trigeminal ganglion triceps brachii muscle biceps brachii muscle of trunk Top expressed in lumbar spinal ganglion lip muscle of thigh aortic valve facial skeleton membranous bone ascending aorta Dermatocranium morula fetal liver hematopoietic progenitor cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function oxidoreductase activity protein binding ferric-chelate reductase (NADPH) activity metal ion binding cupric reductase activity oxidoreductase activity, acting on metal ions, NAD or NADP as acceptor identical protein binding Cellular component integral component of membrane multivesicular body endosome endosome membrane membrane integral component of plasma membrane cytoplasm plasma membrane Biological process apoptotic process protein secretion cell cycle iron ion homeostasis copper ion import ion transport transferrin transport regulation of apoptotic process iron ion import across cell outer membrane Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55240 68428 Ensembl ENSG00000115107 ENSMUSG00000026389 UniProt Q658P3 Q8CI59 RefSeq (mRNA) NM_001008410 NM_018234 NM_138637 NM_182915 NM_001085409 NM_133186 NM_001379354 NM_001379355 RefSeq (protein) NP_001008410 NP_060704 NP_619543 NP_878919 NP_001078878 NP_573449 NP_001366283 NP_001366284 Location (UCSC) Chr 2: 119.22 – 119.27 Mb Chr 1: 120.12 – 120.2 Mb PubMed search [3] [4]
Wikidata
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STEAP3 is a metalloreductase, capable of converting iron from an insoluble ferric (Fe³⁺) to a soluble ferrous (Fe²⁺) form.^[7]

STEAP3 and other STEAP protein, with the exception of STEAP1, are predicted to contain a Di-nucleotide binding domain (Rossmann Fold). This has been shown using X-ray crystallography in the cases of STEAP3 and STEAP4 (PDB: 2VNS, 2VQ3 and 2YJZ).^[8][9]

Interactions

STEAP3 has been shown to interact with BNIP3L^[5] and PKMYT1.^[5]