STEAP4

STEAP family member 4 is a protein that in humans is encoded by the STEAP4 gene.^[5]

STEAP4
Identifiers
Aliases	STEAP4, STAMP2, TIARP, TNFAIP9, STEAP4 metalloreductase, SchLAH
External IDs	OMIM: 611098; MGI: 1923560; HomoloGene: 36422; GeneCards: STEAP4; OMA:STEAP4 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q21.12 Start 88,270,892 bp[1] End 88,306,894 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 A1 Start 8,010,457 bp[2] End 8,032,213 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pericardium palpebral conjunctiva synovial joint vena cava skin of hip subcutaneous adipose tissue tail of epididymis parietal pleura right ventricle bronchial epithelial cell Top expressed in white adipose tissue sciatic nerve mammary gland left lobe of liver intercostal muscle tunica adventitia of aorta ciliary body brown adipose tissue trachea iris More reference expression data BioGPS n/a
Gene ontology Molecular function oxidoreductase activity ferric-chelate reductase (NADPH) activity metal ion binding cupric reductase activity electron transfer activity heme binding FAD binding Cellular component integral component of membrane Golgi membrane plasma membrane extracellular exosome membrane endosome integral component of plasma membrane Golgi apparatus early endosome membrane Biological process iron ion homeostasis copper ion import ion transport fat cell differentiation iron ion import across cell outer membrane transport electron transport chain protein homotrimerization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 79689 117167 Ensembl ENSG00000127954 ENSMUSG00000012428 UniProt Q687X5 Q923B6 RefSeq (mRNA) NM_024636 NM_001205315 NM_001205316 NM_054098 RefSeq (protein) NP_001192244 NP_001192245 NP_078912 NP_473439 Location (UCSC) Chr 7: 88.27 – 88.31 Mb Chr 5: 8.01 – 8.03 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene belongs to the STEAP (six transmembrane epithelial antigen of prostate) family, and resides in the golgi apparatus. It functions as a metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+), using NAD(+) as acceptor. Studies in mice and human suggest that this gene may be involved in adipocyte development and metabolism, and may contribute to the normal biology of the prostate cell, as well as prostate cancer progression. Alternatively spliced transcript variants encoding different isoforms have been found for this gene