STK17A

Serine/threonine kinase 17a is a protein that in humans is encoded by the STK17A gene.^[3]

STK17A
Identifiers
Aliases	STK17A, DRAK1, serine/threonine kinase 17a
External IDs	OMIM: 604726; HomoloGene: 55846; GeneCards: STK17A; OMA:STK17A - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7p13 Start 43,582,758 bp[1] End 43,650,713 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in lymph node epithelium of nasopharynx granulocyte appendix blood bone marrow ganglionic eminence ventricular zone vena cava Achilles tendon n/a More reference expression data BioGPS n/a
Gene ontology Molecular function kinase activity transferase activity nucleotide binding protein kinase activity protein serine/threonine kinase activity ATP binding Cellular component nucleus plasma membrane nuclear speck Biological process positive regulation of apoptotic process positive regulation of fibroblast apoptotic process protein phosphorylation intracellular signal transduction regulation of reactive oxygen species metabolic process phosphorylation apoptotic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9263 n/a Ensembl ENSG00000164543 n/a UniProt Q9UEE5 n/a RefSeq (mRNA) NM_004760 n/a RefSeq (protein) NP_004751 n/a Location (UCSC) Chr 7: 43.58 – 43.65 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Function

This gene is a member of the death-associated protein (DAP) kinase-related apoptosis-inducing protein kinase family and encodes an autophosphorylated nuclear protein with a protein kinase domain. The protein has apoptosis-inducing activity.^[3]

In a recent study the gene (among others) shows a major role in centenarians longer lifespan.^[4]