STK39

STE20/SPS1-related proline-alanine-rich protein kinase is an enzyme that in humans is encoded by the STK39 gene.^[5][6]

STK39
Identifiers
Aliases	STK39, DCHT, PASK, SPAK, serine/threonine kinase 39
External IDs	OMIM: 607648; MGI: 1858416; HomoloGene: 22739; GeneCards: STK39; OMA:STK39 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q24.3 Start 167,954,020 bp[1] End 168,247,595 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 C1.3 Start 68,040,789 bp[2] End 68,302,612 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell Epithelium of choroid plexus pons parotid gland palpebral conjunctiva pars compacta lateral nuclear group of thalamus pars reticulata inferior ganglion of vagus nerve tibia Top expressed in Epithelium of choroid plexus spermatocyte choroid plexus of fourth ventricle spermatid seminiferous tubule tail of embryo salivary gland submandibular gland granulocyte lacrimal gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity protein binding ATP binding protein serine/threonine kinase activity kinase activity protein kinase binding Cellular component membrane basolateral plasma membrane apical plasma membrane cytoskeleton nucleoplasm extrinsic component of membrane intracellular membrane-bounded organelle nucleus cytoplasm cytosol Biological process negative regulation of protein phosphorylation intracellular signal transduction signal transduction phosphorylation positive regulation of potassium ion transport cellular hypotonic response regulation of blood pressure negative regulation of potassium ion transmembrane transporter activity regulation of inflammatory response negative regulation of potassium ion transmembrane transport negative regulation of pancreatic juice secretion peptidyl-threonine phosphorylation positive regulation of ion transmembrane transporter activity maintenance of lens transparency negative regulation of creatine transmembrane transporter activity negative regulation of sodium ion transmembrane transporter activity regulation of mitotic cell cycle stress-activated protein kinase signaling cascade activation of protein kinase activity regulation of apoptotic process protein phosphorylation peptidyl-serine phosphorylation protein autophosphorylation ion homeostasis positive regulation of T cell chemotaxis chemokine (C-X-C motif) ligand 12 signaling pathway cellular response to chemokine Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 27347 53416 Ensembl ENSG00000198648 ENSMUSG00000027030 UniProt Q9UEW8 Q9Z1W9 RefSeq (mRNA) NM_013233 NM_016866 RefSeq (protein) NP_037365 NP_058562 Location (UCSC) Chr 2: 167.95 – 168.25 Mb Chr 2: 68.04 – 68.3 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a serine/threonine kinase that is thought to function in the cellular stress response pathway. The kinase is activated in response to hypotonic stress, leading to phosphorylation of several cation-chloride-coupled cotransporters. The catalytically active kinase specifically activates the p38 MAP kinase pathway, and its interaction with p38 decreases upon cellular stress, suggesting that this kinase may serve as an intermediate in the response to cellular stress.^[6] Some studies suggest that this gene might be linked to high blood pressure.^[7]