STK4

Serine/threonine-protein kinase 4 is an enzyme that in humans is encoded by the STK4 gene.^[5][6][7]

STK4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3COM, 4NR2, 4OH8, 2JO8
Identifiers
Aliases	STK4, KRS2, MST1, TIIAC, YSK3, serine/threonine kinase 4
External IDs	OMIM: 604965; MGI: 1929004; HomoloGene: 55965; GeneCards: STK4; OMA:STK4 - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q13.12 Start 44,966,479 bp[1] End 45,080,021 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 H3 Start 163,912,242 bp[2] End 163,997,444 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in epithelium of colon buccal mucosa cell blood monocyte superficial temporal artery trabecular bone pylorus tonsil lymph node saphenous vein Top expressed in mesenteric lymph nodes blood right lung lobe fossa spleen condyle left lung lobe thymus stroma of bone marrow Gonadal ridge More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity protein kinase activity nucleotide binding protein dimerization activity protein homodimerization activity transcription factor binding protein serine/threonine kinase activator activity metal ion binding kinase activity protein serine/threonine kinase activity protein binding identical protein binding ATP binding magnesium ion binding Cellular component cytoplasm nucleus nucleoplasm cytosol nuclear body protein-containing complex Biological process regulation of cell differentiation involved in embryonic placenta development positive regulation of extrinsic apoptotic signaling pathway via death domain receptors positive regulation of protein phosphorylation intracellular signal transduction phosphorylation protein stabilization hippo signaling keratinocyte differentiation positive regulation of peptidyl-serine phosphorylation endocardium development protein phosphorylation primitive hemopoiesis central nervous system development peptidyl-serine phosphorylation cell morphogenesis positive regulation of apoptotic process branching involved in blood vessel morphogenesis protein autophosphorylation positive regulation of protein binding cell differentiation involved in embryonic placenta development positive regulation of fat cell differentiation negative regulation of organ growth neural tube formation negative regulation of canonical Wnt signaling pathway signal transduction negative regulation of cell population proliferation hepatocyte apoptotic process apoptotic process positive regulation of protein serine/threonine kinase activity regulation of mitotic cell cycle stress-activated protein kinase signaling cascade positive regulation of vascular associated smooth muscle cell apoptotic process activation of protein kinase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6789 58231 Ensembl ENSG00000101109 ENSMUSG00000018209 UniProt Q13043 Q9JI11 RefSeq (mRNA) NM_006282 NM_001352385 NM_021420 RefSeq (protein) NP_006273 NP_001339314 NP_067395 Location (UCSC) Chr 20: 44.97 – 45.08 Mb Chr 2: 163.91 – 164 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene is a cytoplasmic kinase that is structurally similar to the yeast Ste20p (sterile 20 protein) kinase, which acts upstream of the stress-induced mitogen-activated protein kinase (MAPK) cascade. The encoded protein can phosphorylate myelin basic protein and undergoes autophosphorylation. A caspase-cleaved fragment of the encoded protein has been shown to be capable of phosphorylating histone H2B. The particular phosphorylation catalyzed by this protein has been correlated with apoptosis, and it's possible that this protein induces the chromatin condensation observed in this process.^[8]

Interactions

STK4 has been shown to interact with PRKRIR.^[9]

STK4 has also been shown to prevent, through Yap1 coactivator modulation, haematological tumor cell apoptosis.^[10]