STT3B

Dolichyl-diphosphooligosaccharide—protein glycosyltransferase subunit STT3B is an enzyme that in humans is encoded by the STT3B gene.^[5][6][7]

STT3B
Identifiers
Aliases	STT3B, CDG1X, SIMP, STT3-B, catalytic subunit of the oligosaccharyltransferase complex, STT3 oligosaccharyltransferase complex catalytic subunit B
External IDs	OMIM: 608605; MGI: 1915542; HomoloGene: 7387; GeneCards: STT3B; OMA:STT3B - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p23 Start 31,532,638 bp[1] End 31,637,616 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 F3 Start 115,071,649 bp[2] End 115,139,489 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of ileum cardiac muscle tissue of right atrium skin of arm corpus epididymis myocardium of left ventricle thymus Achilles tendon retinal pigment epithelium caput epididymis tibialis anterior muscle Top expressed in seminal vesicula transitional epithelium of urinary bladder lacrimal gland human fetus migratory enteric neural crest cell calvaria epithelium of stomach vas deferens molar left colon More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity oligosaccharyl transferase activity dolichyl-diphosphooligosaccharide-protein glycotransferase activity glycosyltransferase activity metal ion binding protein binding Cellular component integral component of membrane oligosaccharyltransferase complex endoplasmic reticulum membrane endoplasmic reticulum membrane protein-containing complex oligosaccharyltransferase I complex Biological process post-translational protein modification protein glycosylation co-translational protein modification response to unfolded protein protein N-linked glycosylation via asparagine ubiquitin-dependent ERAD pathway glycoprotein catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 201595 68292 Ensembl ENSG00000163527 ENSMUSG00000032437 UniProt Q8TCJ2 Q3TDQ1 RefSeq (mRNA) NM_178862 NM_024222 RefSeq (protein) NP_849193 NP_077184 Location (UCSC) Chr 3: 31.53 – 31.64 Mb Chr 9: 115.07 – 115.14 Mb PubMed search [3] [4]
Wikidata
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Function

The STT3B protein contains a highly immunogenic minor histocompatibility antigen epitope of 9 amino acids, B6(dom1). Like ITM1 (MIM 601134), STT3B is homologous to yeast STT3, an oligosaccharyltransferase essential for cell proliferation.^[8][7]

See also

• Oligosaccharyltransferase