SULT1C2

Sulfotransferase 1C2 is an enzyme that in humans is encoded by the SULT1C2 gene.^[5][6][7]

SULT1C2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3BFX
Identifiers
Aliases	SULT1C2, ST1C1, ST1C2, SULT1C1, humSULTC2, sulfotransferase family 1C member 2
External IDs	OMIM: 602385; MGI: 1916333; HomoloGene: 38201; GeneCards: SULT1C2; OMA:SULT1C2 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q12.3 Start 108,288,639 bp[1] End 108,309,915 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 C Start 54,136,665 bp[2] End 54,153,367 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pylorus kidney tubule renal medulla buccal mucosa cell human kidney gastric mucosa glomerulus corpus epididymis metanephric glomerulus caput epididymis Top expressed in epithelium of stomach pyloric antrum mucous cell of stomach basilar part of occipital bone right kidney human kidney rib splanchnocranium humerus Meckel's cartilage More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity sulfotransferase activity protein binding aryl sulfotransferase activity Cellular component cytoplasm cytosol Biological process amine metabolic process 3'-phosphoadenosine 5'-phosphosulfate metabolic process sulfation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6819 69083 Ensembl ENSG00000198203 ENSMUSG00000023122 UniProt O00338 Q9D939 RefSeq (mRNA) NM_001056 NM_176825 NM_026935 RefSeq (protein) NP_001047 NP_789795 NP_081211 Location (UCSC) Chr 2: 108.29 – 108.31 Mb Chr 17: 54.14 – 54.15 Mb PubMed search [3] [4]
Wikidata
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Function

Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a protein that belongs to the SULT1 subfamily, responsible for transferring a sulfo moiety from PAPS to phenol-containing compounds. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.^[7]