SUMO3

Small ubiquitin-related modifier 3 is a protein that in humans is encoded by the SUMO3 gene.^[5][6]

SUMO3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1U4A, 2IO1, 2MP2
Identifiers
Aliases	SUMO3, SMT3A, SMT3H1, SUMO-3, Smt3B, small ubiquitin-like modifier 3, small ubiquitin like modifier 3
External IDs	OMIM: 602231; MGI: 1336201; HomoloGene: 38251; GeneCards: SUMO3; OMA:SUMO3 - orthologs
Gene location (Human) Chr. Chromosome 21 (human)[1] Band 21q22.3 Start 44,805,617 bp[1] End 44,818,779 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10 C1|10 39.72 cM Start 77,441,931 bp[2] End 77,454,165 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell tibia parietal pleura visceral pleura palpebral conjunctiva germinal epithelium middle temporal gyrus retinal pigment epithelium Brodmann area 23 hair follicle Top expressed in yolk sac neural layer of retina olfactory bulb striatum of neuraxis Mesencephalon epiblast dentate gyrus of hippocampal formation granule cell rhombencephalon stomach Cerebellum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding protein tag enzyme binding ubiquitin-like protein ligase binding Cellular component cytoplasm PML body nucleus kinetochore nucleoplasm Biological process negative regulation of DNA binding protein sumoylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6612 20610 Ensembl ENSG00000184900 ENSMUSG00000020265 UniProt P55854 Q9Z172 RefSeq (mRNA) NM_006936 NM_001286416 NM_001301671 NM_001301672 NM_001301673 NM_019929 RefSeq (protein) NP_001273345 NP_008867 NP_001288600 NP_001288601 NP_001288602 NP_064313 Location (UCSC) Chr 21: 44.81 – 44.82 Mb Chr 10: 77.44 – 77.45 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

SUMO proteins, such as SUMO3, and ubiquitin (see MIM 191339) posttranslationally modify numerous cellular proteins and affect their metabolism and function. However, unlike ubiquitination, which targets proteins for degradation, sumoylation participates in a number of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability (Su and Li, 2002).[supplied by OMIM]^[6]

Interactions

SUMO3 has been shown to interact with ARNTL^[7] and Thymine-DNA glycosylase.^[8]