SUMO4

Small ubiquitin-related modifier 4 is a protein that in humans is encoded by the SUMO4 gene.^[3][4]

SUMO4
Identifiers
Aliases	SUMO4, IDDM5, SMT3H4, SUMO-4, dJ281H8.4, small ubiquitin-like modifier 4, small ubiquitin like modifier 4
External IDs	OMIM: 608829; HomoloGene: 88399; GeneCards: SUMO4; OMA:SUMO4 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q25.1 Start 149,400,262 bp[1] End 149,401,278 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte buccal mucosa cell lactiferous duct pylorus renal medulla optic nerve cardia mucosa of pharynx superior surface of tongue vena cava n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein tag ubiquitin-like protein ligase binding Cellular component nucleus Biological process protein sumoylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 387082 n/a Ensembl ENSG00000177688 n/a UniProt Q6EEV6 n/a RefSeq (mRNA) NM_001002255 n/a RefSeq (protein) NP_001002255 n/a Location (UCSC) Chr 6: 149.4 – 149.4 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Function

This gene is a member of the SUMO gene family. This family of genes encode small ubiquitin-related modifiers that are attached to proteins and control the target proteins' subcellular localization, stability, or activity. The protein described in this record is located in the cytoplasm and specifically modifies IKBA, leading to negative regulation of NF-kappa-B-dependent transcription of the IL12B gene. A specific polymorphism in this SUMO gene, which leads to the M55V substitution, has been associated with type I diabetes. The RefSeq contains this polymorphism.^[4]

Interactions

SUMO4 has been shown to interact with IκBα.^[5]