SUPT16H

FACT complex subunit SPT16 is a protein that in humans is encoded by the SUPT16H gene.^[5][6][7]

SUPT16H
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5E5B, 4Z2M, 4Z2N
Identifiers
Aliases	SUPT16H, CDC68, FACTP140, SPT16/CDC68, SPT16, SPT16 homolog, facilitates chromatin remodeling subunit, NEDDFAC
External IDs	OMIM: 605012; MGI: 1890948; HomoloGene: 5207; GeneCards: SUPT16H; OMA:SUPT16H - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q11.2 Start 21,351,476 bp[1] End 21,384,019 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14 C2|14 26.83 cM Start 52,397,871 bp[2] End 52,434,873 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone ganglionic eminence gonad testicle Achilles tendon epithelium of colon cerebellar hemisphere right hemisphere of cerebellum body of uterus smooth muscle tissue Top expressed in fetal liver hematopoietic progenitor cell genital tubercle tail of embryo neural layer of retina primitive streak renal corpuscle epiblast tibiofemoral joint medullary collecting duct pineal gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding nucleosome binding histone binding RNA binding Cellular component nucleus nucleoplasm chromosome FACT complex Biological process positive regulation of DNA-templated transcription, elongation DNA replication nucleosome disassembly regulation of transcription, DNA-templated transcription by RNA polymerase II DNA repair transcription, DNA-templated cellular response to DNA damage stimulus regulation of signal transduction by p53 class mediator transcription elongation from RNA polymerase II promoter positive regulation of transcription elongation from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11198 114741 Ensembl ENSG00000092201 ENSMUSG00000035726 UniProt Q9Y5B9 Q920B9 RefSeq (mRNA) NM_007192 NM_033618 RefSeq (protein) NP_009123 NP_291096 Location (UCSC) Chr 14: 21.35 – 21.38 Mb Chr 14: 52.4 – 52.43 Mb PubMed search [3] [4]
Wikidata
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Function

Transcription of protein-coding genes can be reconstituted on naked DNA with only the general transcription factors and RNA polymerase II. However, this minimal system cannot transcribe DNA packaged into chromatin, indicating that accessory factors may facilitate access to DNA. One such factor, FACT (facilitates chromatin transcription), interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT is composed of an 80 kDa subunit and a 140 kDa subunit, the latter of which is the protein encoded by this gene.^[7]