SWAP70

Switch-associated protein 70 is a protein that in humans and other mammals is encoded by the SWAP70 gene.^[5][6][7][8]

SWAP70
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DN6
Identifiers
Aliases	SWAP70, SWAP-70, HSPC321, SWAP switching B-cell complex 70kDa subunit, SWAP switching B-cell complex subunit 70, switching B-cell complex subunit switching B cell complex subunit SWAP70
External IDs	OMIM: 604762; MGI: 1298390; HomoloGene: 7557; GeneCards: SWAP70; OMA:SWAP70 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p15.4 Start 9,664,077 bp[1] End 9,752,993 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 E3|7 57.7 cM Start 109,820,918 bp[2] End 109,882,713 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon amniotic fluid sural nerve cartilage tissue visceral pleura lower lobe of lung parietal pleura epithelium of nasopharynx palpebral conjunctiva tibia Top expressed in mesenteric lymph nodes decidua spleen right lung lobe blood left lung lobe stroma of bone marrow calvaria lumbar spinal ganglion femur More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding calcium ion binding protein binding ATP binding cadherin binding Cellular component cell projection membrane plasma membrane cytoskeleton nucleus lamellipodium cytoplasm Biological process positive regulation of cytosolic calcium ion concentration positive regulation of mast cell chemotaxis negative regulation of peptidyl-serine dephosphorylation negative regulation of actin filament depolymerization actin filament bundle assembly regulation of protein localization regulation of actin polymerization or depolymerization somatic cell DNA recombination isotype switching positive regulation of actin filament bundle assembly negative regulation of cell-cell adhesion mediated by integrin Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23075 20947 Ensembl ENSG00000133789 ENSMUSG00000031015 UniProt Q9UH65 Q6A028 RefSeq (mRNA) NM_001297714 NM_015055 NM_009302 RefSeq (protein) NP_001284643 NP_055870 NP_033328 Location (UCSC) Chr 11: 9.66 – 9.75 Mb Chr 7: 109.82 – 109.88 Mb PubMed search [3] [4]
Wikidata
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