SYNGR1

Synaptogyrin-1 is a protein that in humans is encoded by the SYNGR1 gene.^[5][6][7]

SYNGR1
Identifiers
Aliases	SYNGR1, synaptogyrin 1
External IDs	OMIM: 603925; MGI: 1328323; HomoloGene: 3456; GeneCards: SYNGR1; OMA:SYNGR1 - orthologs
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q13.1 Start 39,349,925 bp[1] End 39,385,575 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 E1 Start 79,975,535 bp[2] End 80,003,702 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Brodmann area 10 right hemisphere of cerebellum paraflocculus of cerebellum frontal pole right frontal lobe lateral nuclear group of thalamus cerebellar vermis cingulate gyrus anterior cingulate cortex Brodmann area 9 Top expressed in dentate gyrus of hippocampal formation granule cell superior frontal gyrus cerebellar cortex prefrontal cortex subiculum medial dorsal nucleus dorsal tegmental nucleus medial vestibular nucleus medial geniculate nucleus cerebellar vermis More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component melanosome integral component of membrane cell junction neuromuscular junction synapse synaptic vesicle membrane membrane synaptic vesicle plasma membrane azurophil granule membrane cytoplasmic vesicle integral component of synaptic vesicle membrane Biological process regulation of short-term neuronal synaptic plasticity protein targeting regulation of long-term neuronal synaptic plasticity neutrophil degranulation cellular response to leukemia inhibitory factor regulated exocytosis synaptic vesicle membrane organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9145 20972 Ensembl ENSG00000100321 ENSMUSG00000022415 UniProt O43759 O55100 RefSeq (mRNA) NM_145738 NM_004711 NM_145731 NM_009303 NM_207708 RefSeq (protein) NP_004702 NP_663783 NP_663791 NP_033329 NP_997591 Location (UCSC) Chr 22: 39.35 – 39.39 Mb Chr 15: 79.98 – 80 Mb PubMed search [3] [4]
Wikidata
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This gene encodes an integral membrane protein associated with presynaptic vesicles in neuronal cells. The exact function of this protein is unclear, but studies of a similar murine protein suggest that it functions in synaptic plasticity without being required for synaptic transmission. The gene product belongs to the synaptogyrin gene family. Three alternatively spliced variants encoding three different isoforms have been identified.^[7]