SYTL2

Synaptotagmin-like 2, also known as SYTL2, is a human gene.^[5]

SYTL2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3BC1
Identifiers
Aliases	SYTL2, CHR11SYT, EXO4, PPP1R151, SGA72M, SLP2, SLP2A, synaptotagmin like 2
External IDs	OMIM: 612880; MGI: 1933366; HomoloGene: 131343; GeneCards: SYTL2; OMA:SYTL2 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q14.1 Start 85,694,224 bp[1] End 85,811,159 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 E1 Start 89,951,460 bp[2] End 90,059,927 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in saphenous vein rectum mucosa of sigmoid colon bronchial epithelial cell endothelial cell urethra vena cava right coronary artery tibial arteries mucosa of transverse colon Top expressed in iris epithelium of stomach pyloric antrum transitional epithelium of urinary bladder motor neuron mucous cell of stomach facial motor nucleus zygote hair follicle secondary oocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding phosphatase binding clathrin binding phosphatidylserine binding neurexin family protein binding protein binding calcium-dependent phospholipid binding phosphatidylinositol-4,5-bisphosphate binding syntaxin binding Cellular component cytoplasm exocytic vesicle membrane melanosome plasma membrane extrinsic component of plasma membrane synapse presynapse Biological process negative regulation of phosphatase activity vesicle docking involved in exocytosis protein localization to plasma membrane intracellular protein transport positive regulation of mucus secretion vesicle-mediated transport exocytosis regulation of calcium ion-dependent exocytosis calcium ion-regulated exocytosis of neurotransmitter vesicle fusion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54843 83671 Ensembl ENSG00000137501 ENSMUSG00000030616 UniProt Q9HCH5 Q99N50 RefSeq (mRNA) NM_001162951 NM_001162952 NM_001162953 NM_001289608 NM_001289609 NM_001289610 NM_032379 NM_032943 NM_206927 NM_206928 NM_206929 NM_206930 NM_001365826 NM_001365827 NM_001365828 NM_001365829 NM_001365830 NM_001365831 NM_001365832 NM_001365833 NM_001365834 NM_001365835 NM_001040085 NM_001040086 NM_001040087 NM_001040088 NM_001289583 NM_001289584 NM_001289585 NM_001289586 NM_031394 NM_001368878 RefSeq (protein) NP_001156423 NP_001156424 NP_001156425 NP_001276537 NP_001276538 NP_001276539 NP_116561 NP_996812 NP_996813 NP_001352755 NP_001352756 NP_001352757 NP_001352758 NP_001352759 NP_001352760 NP_001352761 NP_001352762 NP_001352763 NP_001352764 NP_996810 NP_996811 NP_001035174 NP_001035176 NP_001035177 NP_001276512 NP_001276513 NP_001276514 NP_001276515 NP_113571 NP_001355807 Location (UCSC) Chr 11: 85.69 – 85.81 Mb Chr 7: 89.95 – 90.06 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene is a synaptotagmin-like protein (SLP) that belongs to a C2 domain-containing protein family. The SLP homology domain (SHD) of this protein has been shown to specifically bind the GTP-bound form of Ras-related protein Rab-27A (RAB27A), which suggests a role in vesicle trafficking. Multiple alternatively spiced transcript variants encoding distinct isoforms have been observed.^[5]

Interactions

SYTL2 has been shown to interact with RAB27A.^[6][7][8]