Sec61 alpha 1

Protein transport protein Sec61 subunit alpha isoform 1 is a protein encoded by the SEC61A1 gene in humans.^[5]

SEC61A1
Identifiers
Aliases	SEC61A1, HSEC61, SEC61, SEC61A, Sec61 alpha 1, Sec61 translocon alpha 1 subunit, HNFJ4, SEC61 translocon subunit alpha 1, ADTKD5
External IDs	OMIM: 609213; MGI: 1858417; HomoloGene: 55537; GeneCards: SEC61A1; OMA:SEC61A1 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q21.3 Start 128,051,641 bp[1] End 128,071,683 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 D1 Start 88,480,561 bp[2] End 88,495,887 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas stromal cell of endometrium islet of Langerhans anterior pituitary right lobe of liver smooth muscle tissue body of stomach left adrenal gland upper lobe of left lung left adrenal cortex Top expressed in internal carotid artery Ileal epithelium external carotid artery Paneth cell utricle ascending aorta seminal vesicula crypt of lieberkuhn of small intestine lacrimal gland aortic valve More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding ribosome binding signal sequence binding protein transmembrane transporter activity calcium channel activity Cellular component integral component of membrane cytosol rough endoplasmic reticulum integral component of endoplasmic reticulum membrane endoplasmic reticulum membrane endoplasmic reticulum membrane Sec61 Biological process response to interferon-gamma endoplasmic reticulum organization SRP-dependent cotranslational protein targeting to membrane posttranslational protein targeting to endoplasmic reticulum membrane protein targeting to ER protein transport pronephric nephron development cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane, translocation posttranslational protein targeting to membrane, translocation calcium ion transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 29927 53421 Ensembl ENSG00000058262 ENSMUSG00000030082 UniProt P61619 P61620 RefSeq (mRNA) NM_013336 NM_001400328 NM_001400329 NM_016906 RefSeq (protein) NP_037468 NP_058602 Location (UCSC) Chr 3: 128.05 – 128.07 Mb Chr 6: 88.48 – 88.5 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene belongs to the SecY/Sec61α family. It plays a crucial role in the insertion of secretory and membrane polypeptides into the endoplasmic reticulum. This protein is found to be tightly associated with membrane-bound ribosomes, either directly or through adaptor proteins. This gene encodes an alpha subunit of the heteromeric SEC61 complex, which contains beta and gamma subunits.^[5]