Secretin receptor

The secretin receptor is a protein that in humans is encoded by the SCTR gene. This protein is a G protein-coupled receptor which binds secretin and is the leading member (i.e., first cloned) of the secretin receptor family, also called class B GPCR subfamily.^[5]

SCTR
Identifiers
Aliases	SCTR, SR, secretin receptor
External IDs	OMIM: 182098; MGI: 2441720; HomoloGene: 68290; GeneCards: SCTR; OMA:SCTR - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q14.2 Start 119,439,843 bp[1] End 119,525,301 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 E2.3 Start 119,934,624 bp[2] End 119,991,266 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas testicle islet of Langerhans duodenum right lung upper lobe of left lung body of stomach human kidney gallbladder right uterine tube Top expressed in muscle of thigh epithelium of stomach morula knee joint lumbar subsegment of spinal cord soleus muscle tibialis anterior muscle vastus lateralis muscle temporal muscle upper arm More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity transmembrane signaling receptor activity signal transducer activity secretin receptor activity peptide hormone binding G protein-coupled peptide receptor activity Cellular component integral component of membrane cytoplasmic microtubule plasma membrane membrane Biological process cell surface receptor signaling pathway signal transduction G protein-coupled receptor signaling pathway brain development diet induced thermogenesis cellular water homeostasis response to nutrient levels regulation of appetite positive regulation of cAMP-mediated signaling regulation of synaptic plasticity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6344 319229 Ensembl ENSG00000080293 ENSMUSG00000026387 UniProt P47872 Q5FWI2 RefSeq (mRNA) NM_002980 NM_001012322 NM_001311077 RefSeq (protein) NP_002971 NP_001012322 NP_001298006 Location (UCSC) Chr 2: 119.44 – 119.53 Mb Chr 1: 119.93 – 119.99 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

The secretin receptor has been shown to interact with pituitary adenylate cyclase activating peptide.^[6]