Selenophosphate synthetase 1

Selenide, water dikinase 1 is an enzyme that in humans is encoded by the SEPHS1 gene.^[5][6]

SEPHS1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3FD5, 3FD6
Identifiers
Aliases	SEPHS1, SELD, SPS, SPS1, Selenophosphate synthetase 1
External IDs	OMIM: 600902; MGI: 1923580; HomoloGene: 56558; GeneCards: SEPHS1; OMA:SEPHS1 - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10p13 Start 13,317,428 bp[1] End 13,348,298 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 A1 Start 4,881,564 bp[2] End 4,910,557 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone ganglionic eminence islet of Langerhans buccal mucosa cell oocyte olfactory zone of nasal mucosa secondary oocyte rectum internal globus pallidus right lobe of liver Top expressed in genital tubercle tail of embryo ventricular zone maxillary prominence mandibular prominence condyle ganglionic eminence abdominal wall primitive streak internal carotid artery More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding selenide, water dikinase activity GTP binding protein binding ATP binding protein homodimerization activity identical protein binding protein heterodimerization activity kinase activity Cellular component cytoplasm plasma membrane nuclear membrane membrane nucleus Biological process phosphorylation selenocysteine biosynthetic process selenium compound metabolic process tRNA seleno-modification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 22929 109079 Ensembl ENSG00000086475 ENSMUSG00000026662 UniProt P49903 Q5T5U7 Q8BH69 RefSeq (mRNA) NM_001195602 NM_001195604 NM_012247 NM_001375769 NM_001375770 NM_175400 RefSeq (protein) NP_001182531 NP_001182533 NP_036379 NP_001362698 NP_780609 NP_001349636 NP_001349637 NP_001349638 NP_001349639 Location (UCSC) Chr 10: 13.32 – 13.35 Mb Chr 2: 4.88 – 4.91 Mb PubMed search [3] [4]
Wikidata
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This protein functions as an enzyme that synthesizes selenophosphate from selenide and ATP. Selenophosphate is the selenium donor used to synthesize selenocysteine, which is co-translationally incorporated into selenoproteins at in-frame UGA codons.^[6]