Semaphorin 3E

Semaphorin 3E is a protein that in humans is encoded by the SEMA3E gene. ^[4]

SEMA3E
Identifiers
Aliases	SEMA3E, M-SEMAH, M-SemaK, SEMAH, coll-5, semaphorin 3E
External IDs	OMIM: 608166; MGI: 1340034; HomoloGene: 8247; GeneCards: SEMA3E; OMA:SEMA3E - orthologs
Gene location (Mouse) Chr. Chromosome 5 (mouse)[1] Band 5|5 A1 Start 14,075,290 bp[1] End 14,306,703 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon islet of Langerhans gallbladder gastric mucosa synovial membrane urinary bladder synovial joint rectum prefrontal cortex ganglionic eminence Top expressed in lumbar spinal ganglion pontine nuclei decidua habenula gastrula right lung right lung lobe vestibular membrane of cochlear duct Region I of hippocampus proper substantia nigra More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding neuropilin binding semaphorin receptor binding chemorepellent activity Cellular component extracellular region extracellular space integral component of plasma membrane Biological process cell differentiation nervous system development multicellular organism development angiogenesis negative chemotaxis branching involved in blood vessel morphogenesis negative regulation of cell-matrix adhesion sprouting angiogenesis regulation of cell shape negative regulation of angiogenesis synapse organization semaphorin-plexin signaling pathway regulation of actin cytoskeleton reorganization neural crest cell migration positive regulation of cell migration negative regulation of axon extension involved in axon guidance Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9723 20349 Ensembl n/a ENSMUSG00000063531 UniProt O15041 P70275 RefSeq (mRNA) NM_001178129 NM_012431 NM_011348 RefSeq (protein) NP_001171600 NP_036563 NP_035478 Location (UCSC) n/a Chr 5: 14.08 – 14.31 Mb PubMed search [2] [3]
Wikidata
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Function

Semaphorin are a large family of conserved secreted and membrane associated proteins which possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Based on sequence and structural similarities, semaphorins are put into eight classes: invertebrates contain classes 1 and 2, viruses have class V, and vertebrates contain classes 3-7. Semaphorins serve as axon guidance ligands via multimeric receptor complexes, some (if not all) containing plexin proteins.

This gene encodes a class 3 semaphorin. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010].