Set domain containing 1b

SET domain containing 1B is a protein that in humans is encoded by the SETD1B gene. ^[5]

SETD1B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3UVO, 4ES0
Identifiers
Aliases	SETD1B, KMT2G, Set1B, SET domain containing 1B, SET domain containing 1B, histone lysine methyltransferase, IDDSELD
External IDs	OMIM: 611055; MGI: 2652820; HomoloGene: 137311; GeneCards: SETD1B; OMA:SETD1B - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q24.31 Start 121,804,009 bp[1] End 121,832,656 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 F Start 123,280,256 bp[2] End 123,306,692 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in hair follicle parietal pleura cardia visceral pleura urethra nipple saphenous vein germinal epithelium seminal vesicula pylorus Top expressed in hand otolith organ utricle mesenteric lymph nodes ascending aorta cervix blood granulocyte Gonadal ridge aortic valve More reference expression data BioGPS n/a
Gene ontology Molecular function nucleic acid binding methyltransferase activity transferase activity protein binding histone methyltransferase activity (H3-K4 specific) RNA binding histone-lysine N-methyltransferase activity Cellular component histone methyltransferase complex nuclear speck nucleus chromosome nucleoplasm cytosol Set1C/COMPASS complex Biological process methylation regulation of transcription, DNA-templated transcription, DNA-templated histone H3-K4 methylation chromatin organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23067 208043 Ensembl ENSG00000139718 ENSMUSG00000038384 UniProt Q9UPS6 Q8CFT2 RefSeq (mRNA) NM_015048 NM_001353345 NM_001040398 NM_177581 RefSeq (protein) NP_001340274 NP_001035488 Location (UCSC) Chr 12: 121.8 – 121.83 Mb Chr 5: 123.28 – 123.31 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

SET1B is a component of a histone methyltransferase complex that produces trimethylated histone H3 at Lys4 (Lee et al., 2007 [PubMed 17355966]).[supplied by OMIM, Mar 2008].