SIVA1

Apoptosis regulatory protein Siva is a protein that in humans is encoded by the SIVA1 gene.^[5][6] This gene encodes a protein with an important role in the apoptotic (programmed cell death) pathway induced by the CD27 antigen, a member of the tumor necrosis factor receptor (TFNR) superfamily. The CD27 antigen cytoplasmic tail binds to the N-terminus of this protein. Two alternatively spliced transcript variants encoding distinct proteins have been described.^[6]

SIVA1
Identifiers
Aliases	SIVA1, CD27BP, SIVA, Siva-1, Siva-2, SIVA1 apoptosis inducing factor
External IDs	OMIM: 605567; MGI: 1353606; HomoloGene: 4692; GeneCards: SIVA1; OMA:SIVA1 - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q32.33 Start 104,753,147 bp[1] End 104,768,494 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 F1 Start 112,611,113 bp[2] End 112,615,583 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in popliteal artery tibial arteries gastric mucosa thoracic aorta ascending aorta muscle of thigh anterior pituitary right testis left testis muscle layer of sigmoid colon Top expressed in otic placode renal corpuscle medullary collecting duct embryo embryo Gonadal ridge condyle zygote otic vesicle fossa More reference expression data BioGPS More reference expression data
Gene ontology Molecular function zinc ion binding protein binding metal ion binding virus receptor activity tumor necrosis factor receptor binding CD27 receptor binding Cellular component cytoplasm mitochondrion nucleus nucleoplasm intracellular anatomical structure Biological process apoptotic process intrinsic apoptotic signaling pathway viral process activation-induced cell death of T cells negative regulation of NF-kappaB transcription factor activity positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway extrinsic apoptotic signaling pathway viral entry into host cell Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10572 30954 Ensembl ENSG00000184990 ENSMUSG00000064326 UniProt O15304 O54926 RefSeq (mRNA) NM_006427 NM_021709 NM_001161737 NM_013929 RefSeq (protein) NP_006418 NP_068355 NP_001155209 NP_038957 Location (UCSC) Chr 14: 104.75 – 104.77 Mb Chr 12: 112.61 – 112.62 Mb PubMed search [3] [4]
Wikidata
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Interactions

SIVA1 has been shown to interact with CD27.^[5]

Siva (protein)

Siva protein is a zinc-containing intracellular ligand of the CD4 receptor that promotes HIV-1 envelope-induced apoptosis in T-lymphoid cells. Recent research has demonstrated that Siva is a direct transcriptional target for the tumor-suppressors p53 and E2F1. ^[7]

See also

• Siva (protein)