Solute carrier organic anion transporter family member 4c1

Solute carrier organic anion transporter family member 4C1 is a protein that in humans is encoded by the SLCO4C1 gene, which is located on chromosome 5q21. The OATP4C1 protein is expressed in the basolateral membrane of the nephron of the human kidney, where it is involved in the uptake of organic anions for elimination in the urine. The drug digoxin is an important substrate of this transporter.^[5][6]

SLCO4C1
Identifiers
Aliases	SLCO4C1, OATP-H, OATP-M1, OATP4C1, OATPX, PRO2176, SLC21A20, solute carrier organic anion transporter family member 4C1
External IDs	OMIM: 609013; MGI: 2442784; HomoloGene: 62654; GeneCards: SLCO4C1; OMA:SLCO4C1 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q21.1 Start 102,233,986 bp[1] End 102,296,284 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 D Start 96,743,995 bp[2] End 96,799,896 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in kidney tubule palpebral conjunctiva renal medulla lower lobe of lung glomerulus mucosa of paranasal sinus metanephric glomerulus human kidney bronchial epithelial cell bone marrow Top expressed in seminal vesicula left lung lobe granulocyte prostate lobe of prostate nasal epithelium olfactory epithelium lacrimal gland yolk sac conjunctival fornix More reference expression data BioGPS n/a
Gene ontology Molecular function transporter activity sodium-independent organic anion transmembrane transporter activity Cellular component integral component of membrane plasma membrane basolateral plasma membrane extracellular exosome membrane azurophil granule membrane specific granule membrane integral component of plasma membrane Biological process multicellular organism development cell differentiation ion transport spermatogenesis neutrophil degranulation sodium-independent organic anion transport transport transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 353189 227394 Ensembl ENSG00000173930 ENSMUSG00000040693 UniProt Q6ZQN7 Q8BGD4 RefSeq (mRNA) NM_180991 NM_172658 RefSeq (protein) NP_851322 NP_766246 Location (UCSC) Chr 5: 102.23 – 102.3 Mb Chr 1: 96.74 – 96.8 Mb PubMed search [3] [4]
Wikidata
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Function

SLCO4C1 belongs to the organic anion transporter (OATP) family. OATPs are involved in the membrane transport of bile acids, conjugated steroids, thyroid hormone, eicosanoids, peptides, and numerous drugs in many tissues (Mikkaichi et al., 2004 [PubMed 14993604]).