Synaptonemal complex central element protein 1

Synaptonemal complex central element protein 1 is a protein that in humans is encoded by the SYCE1 gene. ^[5]

SYCE1
Identifiers
Aliases	SYCE1, C10orf94, CT76, synaptonemal complex central element protein 1, POF12, SPGF15
External IDs	OMIM: 611486; MGI: 1921325; HomoloGene: 77044; GeneCards: SYCE1; OMA:SYCE1 - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q26.3 Start 133,553,901 bp[1] End 133,569,835 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 F4|7 Start 140,357,142 bp[2] End 140,367,765 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right testis left testis gonad right hemisphere of cerebellum right frontal lobe testicle anterior cingulate cortex Brodmann area 9 prefrontal cortex nucleus accumbens Top expressed in seminiferous tubule spermatocyte spermatid embryo morula embryo zygote ovary Gonadal ridge epiblast More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding Cellular component synaptonemal complex central element nucleus chromosome Biological process cell cycle meiosis synaptonemal complex organization synaptonemal complex assembly cell division Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 93426 74075 Ensembl ENSG00000171772 ENSMUSG00000025480 UniProt Q8N0S2 Q9D495 RefSeq (mRNA) NM_201564 NM_001143763 NM_001143764 NM_130784 NM_001143765 RefSeq (protein) NP_001137235 NP_570140 NP_001137236 NP_001137237 Location (UCSC) Chr 10: 133.55 – 133.57 Mb Chr 7: 140.36 – 140.37 Mb PubMed search [3] [4]
Wikidata
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Primary ovarian insufficiency can be caused by mutations in genes involved in essential steps in chromosome synapsis and recombination during meiosis. Mutation in the autosomal gene SYCE1 that encodes synaptonemal complex element 1 protein causes a primary ovarian insufficiency phenotype in humans.^[6] This finding highlights the importance of the synaptonemal complex and meiosis for ovarian function.