T-cell activation RhoGTPase activating protein

T-cell activation RhoGTPase activating protein is a protein that in humans is encoded by the TAGAP gene. ^[5]

TAGAP
Identifiers
Aliases	TAGAP, ARHGAP47, IDDM21, TAGAP1, FKSG15, T-cell activation RhoGTPase activating protein, T cell activation RhoGTPase activating protein
External IDs	OMIM: 609667; MGI: 3615484; HomoloGene: 44943; GeneCards: TAGAP; OMA:TAGAP - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q25.3 Start 159,034,468 bp[1] End 159,045,152 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 A1 Start 8,144,832 bp[2] End 8,153,729 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bone marrow cells blood granulocyte monocyte appendix trabecular bone lymph node mucosa of ileum superficial temporal artery spleen Top expressed in granulocyte spleen uterus spermatocyte bone marrow thymus urinary bladder adrenal gland morula white adipose tissue More reference expression data BioGPS n/a
Gene ontology Molecular function guanyl-nucleotide exchange factor activity GTPase activator activity Cellular component cytosol Biological process positive regulation of GTPase activity regulation of small GTPase mediated signal transduction signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 117289 72536 Ensembl ENSG00000164691 ENSMUSG00000033450 UniProt Q8N103 B2RWW0 RefSeq (mRNA) NM_152133 NM_001278733 NM_054114 NM_138810 NM_145968 RefSeq (protein) NP_001265662 NP_473455 NP_620165 NP_687034 NP_666080 Location (UCSC) Chr 6: 159.03 – 159.05 Mb Chr 17: 8.14 – 8.15 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a member of the Rho GTPase-activator protein superfamily. The encoded protein may function as a Rho GTPase-activating protein. Alterations in this gene may be associated with several diseases, including rheumatoid arthritis, celiac disease, and multiple sclerosis. Alternate splicing results in multiple transcript variants encoding distinct isoforms.