TAF12

Transcription initiation factor TFIID subunit 12 is a protein that in humans is encoded by the TAF12 gene.^[5][6]

TAF12
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1H3O
Identifiers
Aliases	TAF12, TAF2J, TAFII20, TATA-box binding protein associated factor 12
External IDs	OMIM: 600773; MGI: 1913714; HomoloGene: 68477; GeneCards: TAF12; OMA:TAF12 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p35.3 Start 28,587,829 bp[1] End 28,648,291 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 D2.3 Start 132,001,686 bp[2] End 132,023,077 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte monocyte gastrocnemius muscle testicle Achilles tendon muscle of thigh granulocyte apex of heart right testis left testis Top expressed in zygote interventricular septum granulocyte muscle of thigh right kidney fetal liver hematopoietic progenitor cell secondary oocyte extraocular muscle digastric muscle morula More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding DNA-binding transcription factor activity transcription coactivator activity transcription factor binding protein binding protein heterodimerization activity TBP-class protein binding histone acetyltransferase activity Cellular component transcription factor TFTC complex transcription factor TFIID complex nucleoplasm nucleus SAGA complex SLIK (SAGA-like) complex Biological process regulation of transcription, DNA-templated positive regulation of DNA-binding transcription factor activity transcription by RNA polymerase II transcription, DNA-templated DNA-templated transcription, initiation transcription initiation from RNA polymerase II promoter regulation of signal transduction by p53 class mediator RNA polymerase II preinitiation complex assembly histone H3 acetylation positive regulation of nucleic acid-templated transcription Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6883 66464 Ensembl ENSG00000120656 ENSMUSG00000028899 UniProt Q16514 Q8VE65 RefSeq (mRNA) NM_001135218 NM_005644 NM_025579 RefSeq (protein) NP_001128690 NP_005635 NP_079855 Location (UCSC) Chr 1: 28.59 – 28.65 Mb Chr 4: 132 – 132.02 Mb PubMed search [3] [4]
Wikidata
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Function

Control of transcription by RNA polymerase II involves the basal transcription machinery, which is a collection of proteins. These proteins with RNA polymerase II, assemble into complexes that are modulated by transactivator proteins that bind to cis-regulatory elements located adjacent to the transcription start site. Some modulators interact directly with the basal complex, whereas others may act as bridging proteins linking transactivators to the basal transcription factors. Some of these associated factors are weakly attached, whereas others are tightly associated with TBP in the TFIID complex. Among the latter are the TAF proteins. Different TAFs are predicted to mediate the function of distinct transcriptional activators for a variety of gene promoters and RNA polymerases. TAF12 interacts directly with TBP as well as with TAF2I.^[6]

Interactions

TAF12 has been shown to interact with TAF9^[7] and Transcription initiation protein SPT3 homolog.^[7]