TAF2

Transcription initiation factor TFIID subunit 2 is a protein that in humans is encoded by the TAF2 gene.^[5][6][7]

TAF2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5FUR
Identifiers
Aliases	TAF2, CIF150, MRT40, TAF2B, TAFII150, TATA-box binding protein associated factor 2
External IDs	OMIM: 604912; MGI: 2443028; HomoloGene: 31137; GeneCards: TAF2; OMA:TAF2 - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q24.12 Start 119,730,774 bp[1] End 119,832,863 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 D1 Start 54,878,527 bp[2] End 54,935,548 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell Achilles tendon corpus epididymis tail of epididymis Epithelium of choroid plexus ventricular zone caput epididymis skin of hip epithelium of nasopharynx germinal epithelium Top expressed in hand genital tubercle tail of embryo Gonadal ridge superior cervical ganglion spermatocyte otolith organ utricle mandibular prominence maxillary prominence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function sequence-specific DNA binding chromatin binding protein binding TFIID-class transcription factor complex binding RNA polymerase II general transcription initiation factor activity Cellular component transcription factor TFTC complex transcription factor TFIID complex nucleoplasm nucleus Biological process regulation of transcription, DNA-templated response to organic cyclic compound transcription by RNA polymerase II transcription, DNA-templated G2/M transition of mitotic cell cycle transcription initiation from RNA polymerase II promoter positive regulation of transcription by RNA polymerase II RNA polymerase II preinitiation complex assembly regulation of signal transduction by p53 class mediator Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6873 319944 Ensembl ENSG00000064313 ENSMUSG00000037343 UniProt Q6P1X5 Q8C176 RefSeq (mRNA) NM_003184 NM_001081288 NM_177040 RefSeq (protein) NP_003175 NP_001074757 Location (UCSC) Chr 8: 119.73 – 119.83 Mb Chr 15: 54.88 – 54.94 Mb PubMed search [3] [4]
Wikidata
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Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the larger subunits of TFIID that is stably associated with the TFIID complex. It contributes to interactions at and downstream of the transcription initiation site, interactions that help determine transcription complex response to activators.^[7]