TAF5L

TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L is an enzyme that in humans is encoded by the TAF5L gene.^[5][6][7]

TAF5L
Identifiers
Aliases	TAF5L, PAF65B, TATA-box binding protein associated factor 5 like
External IDs	MGI: 1919039; HomoloGene: 8676; GeneCards: TAF5L; OMA:TAF5L - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q42.13 Start 229,593,121 bp[1] End 229,626,047 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 E2 Start 124,723,057 bp[2] End 124,748,136 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell popliteal artery tibial arteries secondary oocyte right coronary artery thoracic aorta ascending aorta Descending thoracic aorta monocyte gastrocnemius muscle Top expressed in interventricular septum otic vesicle genital tubercle tail of embryo otic placode saccule spermatid epiblast thymus hair follicle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity transcription coactivator activity protein binding histone acetyltransferase activity Cellular component nuclear speck nucleus cytoplasmic ribonucleoprotein granule transcription factor TFTC complex Biological process regulation of transcription, DNA-templated transcription by RNA polymerase II histone H3 acetylation transcription, DNA-templated positive regulation of nucleic acid-templated transcription Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 27097 102162 Ensembl ENSG00000135801 ENSMUSG00000038697 UniProt O75529 Q91WQ5 RefSeq (mRNA) NM_001025247 NM_014409 NM_133966 NM_001357315 RefSeq (protein) NP_001020418 NP_055224 NP_598727 NP_001344244 Location (UCSC) Chr 1: 229.59 – 229.63 Mb Chr 8: 124.72 – 124.75 Mb PubMed search [3] [4]
Wikidata
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Function

The product of this gene belongs to the WD-repeat TAF5 family of proteins. This gene encodes a protein that is a component of the PCAF histone acetylase complex. The PCAF histone acetylase complex, which is composed of more than 20 polypeptides some of which are TAFs, is required for myogenic transcription and differentiation. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors to facilitate complex assembly and transcription initiation. The encoded protein is structurally similar to one of the histone-like TAFs, TAF5. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.^[7]

Interactions

TAF5L has been shown to interact with TAF9^[8] and Transcription initiation protein SPT3 homolog.^[8]