TAF6

Transcription initiation factor TFIID subunit 6 is a protein that in humans is encoded by the TAF6 gene.^[5]

TAF6
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5FUR
Identifiers
Aliases	TAF6, MGC:8964, TAF(II)70, TAF(II)80, TAF2E, TAFII-70, TAFII-80, TAFII70, TAFII80, TAFII85, TATA-box binding protein associated factor 6, ALYUS
External IDs	OMIM: 602955; MGI: 109129; HomoloGene: 7561; GeneCards: TAF6; OMA:TAF6 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q22.1 Start 100,106,876 bp[1] End 100,119,841 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 G2 Start 138,176,879 bp[2] End 138,185,713 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium right hemisphere of cerebellum right frontal lobe body of uterus pituitary gland anterior pituitary canal of the cervix right ovary cingulate gyrus anterior cingulate cortex Top expressed in genital tubercle tail of embryo ventricular zone yolk sac muscle of thigh neural layer of retina right kidney neural tube internal carotid artery spermatid More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity DNA binding protein binding protein heterodimerization activity aryl hydrocarbon receptor binding Cellular component MLL1 complex transcription factor TFTC complex cytosol nucleus nucleoplasm SAGA complex transcription factor TFIID complex SLIK (SAGA-like) complex protein-containing complex Biological process negative regulation of cell cycle transcription initiation from RNA polymerase II promoter transcription by RNA polymerase II regulation of DNA-binding transcription factor activity transcription, DNA-templated DNA-templated transcription, initiation negative regulation of cell population proliferation regulation of transcription, DNA-templated snRNA transcription by RNA polymerase II regulation of signal transduction by p53 class mediator chromatin organization RNA polymerase II preinitiation complex assembly regulation of transcription by RNA polymerase II apoptotic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6878 21343 Ensembl ENSG00000106290 ENSMUSG00000036980 UniProt P49848 Q62311 RefSeq (mRNA) NM_001190415 NM_005641 NM_139122 NM_139123 NM_139315 NM_001364998 NM_001364999 NM_001365000 NM_001365001 NM_001365002 NM_001365003 NM_001365004 NM_009315 NM_001356600 NM_001356601 NM_001356602 RefSeq (protein) NP_001177344 NP_005632 NP_647476 NP_001351927 NP_001351928 NP_001351929 NP_001351930 NP_001351931 NP_001351932 NP_001351933 NP_033341 NP_001343529 NP_001343530 NP_001343531 Location (UCSC) Chr 7: 100.11 – 100.12 Mb Chr 5: 138.18 – 138.19 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the smaller subunits of TFIID that binds weakly to TBP but strongly to TAF1, the largest subunit of TFIID. Four isoforms have been identified but complete transcripts have been determined for only three isoforms. One of the isoforms has been shown to preclude binding of one of the other TFIID subunits, thereby reducing transcription and initiating signals that trigger apoptosis.^[6]

Interactions

TAF6 has been shown to interact with:

• TAF5^[7][8] and
• TATA binding protein.^[9][10][11]