TAL2

T-cell acute lymphocytic leukemia 2, also known as TAL2, is a protein which in humans is encoded by the TAL2 gene.^[5][6]

TAL2
Identifiers
Aliases	TAL2, TAL bHLH transcription factor 2
External IDs	OMIM: 186855; MGI: 99540; HomoloGene: 3954; GeneCards: TAL2; OMA:TAL2 - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q31.2 Start 105,662,457 bp[1] End 105,663,124 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 B2|4 28.75 cM Start 53,779,705 bp[2] End 53,788,712 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Skeletal muscle tissue of rectus abdominis Skeletal muscle tissue of biceps brachii vastus lateralis muscle buccal mucosa cell muscle of thigh deltoid muscle renal medulla ganglionic eminence ventricular zone gastrocnemius muscle Top expressed in pineal gland embryo granulocyte temporal muscle spermatid hair follicle seminiferous tubule muscle of thigh skeletal muscle tissue esophagus More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding protein binding protein dimerization activity DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus Biological process regulation of transcription, DNA-templated post-embryonic development transcription, DNA-templated midbrain development multicellular organism growth thalamus development regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6887 21350 Ensembl ENSG00000186051 ENSMUSG00000028417 UniProt Q16559 Q62282 RefSeq (mRNA) NM_005421 NM_009317 RefSeq (protein) NP_005412 NP_033343 Location (UCSC) Chr 9: 105.66 – 105.66 Mb Chr 4: 53.78 – 53.79 Mb PubMed search [3] [4]
Wikidata
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Function

TAL2 is a member of the basic helix-loop-helix family of transcription factors.^[7]

Clinical significance

Tumor-specific alterations of the TAL2 gene occurs in some patients with T-cell acute lymphoblastic leukemia (T-ALL).^[6][8]