TAP2

TAP2 is a gene in humans that encodes the protein Antigen peptide transporter 2.^[5][6][7]

TAP2
Identifiers
Aliases	TAP2, ABC18, ABCB3, APT2, D6S217E, PSF-2, PSF2, RING11, transporter 2, ATP-binding cassette, sub-family B (MDR/TAP), transporter 2, ATP binding cassette subfamily B member
External IDs	OMIM: 170261; MGI: 98484; HomoloGene: 37323; GeneCards: TAP2; OMA:TAP2 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p21.32 Start 32,821,833 bp[1] End 32,838,739 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17 B1|17 17.98 cM Start 34,422,501 bp[2] End 34,435,295 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in appendix lymph node monocyte granulocyte duodenum apex of heart spleen stromal cell of endometrium mucosa of transverse colon blood Top expressed in thymus granulocyte mesenteric lymph nodes lactiferous gland spleen duodenum subcutaneous adipose tissue jejunum bone marrow submandibular gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function MHC protein binding ATPase-coupled transmembrane transporter activity nucleotide binding ABC-type peptide transporter activity transporter activity tapasin binding MHC class Ib protein binding ABC-type peptide antigen transporter activity ATPase activity protein binding TAP1 binding ATP binding peptide transmembrane transporter activity MHC class I protein binding TAP2 binding Cellular component TAP complex endoplasmic reticulum membrane membrane integral component of endoplasmic reticulum membrane integral component of membrane endoplasmic reticulum nuclear speck phagocytic vesicle membrane endoplasmic reticulum-Golgi intermediate compartment membrane MHC class I peptide loading complex Biological process adaptive immune response immune system process antigen processing and presentation of peptide antigen via MHC class I antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent transmembrane transport protein transport peptide transport viral process cytosol to endoplasmic reticulum transport antigen processing and presentation of endogenous peptide antigen via MHC class I peptide antigen transport antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6891 21355 Ensembl ENSG00000204267 ENSG00000206299 ENSG00000228582 ENSG00000206235 ENSG00000225967 ENSG00000237599 ENSG00000223481 ENSG00000232326 ENSMUSG00000024339 UniProt Q03519 P36371 RefSeq (mRNA) NM_018833 NM_000544 NM_001290043 NM_011530 RefSeq (protein) NP_000535 NP_001276972 NP_061313 NP_035660 Location (UCSC) Chr 6: 32.82 – 32.84 Mb Chr 17: 34.42 – 34.44 Mb PubMed search [3] [4]
Wikidata
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Function

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This gene is located 7 kb telomeric to gene family member ABCB2 (TAP1). The protein encoded by this gene is involved in antigen presentation. This protein forms a heterodimer with ABCB2 in order to transport peptides from the cytoplasm to the endoplasmic reticulum. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, schizophrenia,^[8] and celiac disease. Alternative splicing of this gene produces two products which differ in peptide selectivity and level of restoration of surface expression of MHC class I molecules.^[9]

See also

• ATP-binding cassette transporter