TAS2R31

Taste receptor, type 2, member 31, also known as TAS2R31, is a protein which in humans is encoded by the TAS2R31 gene.^[5] This bitter taste receptor has been shown to respond to saccharin in vitro.^[6]

TAS2R31
Identifiers
Aliases	TAS2R31, T2R31, T2R44, T2R53, TAS2R44, taste 2 receptor member 31
External IDs	OMIM: 612669; MGI: 2681304; HomoloGene: 136304; GeneCards: TAS2R31; OMA:TAS2R31 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12p13.2 Start 11,030,387 bp[1] End 11,031,407 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 G1|6 64.03 cM Start 132,754,142 bp[2] End 132,755,125 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle corpus callosum Achilles tendon tonsil epithelium of colon endometrium stromal cell of endometrium left ovary gastric mucosa right ovary n/a More reference expression data BioGPS n/a
Gene ontology Molecular function signal transducer activity G protein-coupled receptor activity bitter taste receptor activity Cellular component plasma membrane membrane integral component of membrane Biological process detection of chemical stimulus involved in sensory perception of bitter taste sensory perception of taste signal transduction response to stimulus G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 259290 353165 Ensembl ENSG00000256436 ENSG00000263097 ENSG00000282256 ENSMUSG00000053217 UniProt P59538 Q7TQA8 RefSeq (mRNA) NM_176885 NM_181276 RefSeq (protein) NP_795366 NP_851793 Location (UCSC) Chr 12: 11.03 – 11.03 Mb Chr 6: 132.75 – 132.76 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

TAS2R31 is also expressed in the smooth muscle of human airways, along with several other bitter taste receptors. Their activation in these cells causes an increase in intracellular calcium ion, which in turn triggers the opening of potassium channels which hyperpolarize the membrane and cause the smooth muscle to relax. Hence, activation of these receptors leads to bronchodilation.^[7]

Polymorphisms in this gene have been associated with the perceived bitterness of sweetener acesulfame potassium.^[8]

See also

• Taste receptor