TCEA2

Transcription elongation factor A protein 2 is a protein that in humans is encoded by the TCEA2 gene.^[5][6][7]

TCEA2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2LW4
Identifiers
Aliases	TCEA2, TFIIS, transcription elongation factor A2
External IDs	OMIM: 604784; MGI: 107368; HomoloGene: 68304; GeneCards: TCEA2; OMA:TCEA2 - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q13.33 Start 64,049,836 bp[1] End 64,072,347 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 H4|2 103.72 cM Start 181,322,103 bp[2] End 181,329,864 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum right frontal lobe left testis right testis nucleus accumbens prefrontal cortex cingulate gyrus anterior cingulate cortex anterior pituitary ventricular zone Top expressed in spermatocyte spermatid seminiferous tubule superior frontal gyrus primary visual cortex dentate gyrus of hippocampal formation granule cell facial motor nucleus cerebellar cortex granulocyte anterior horn of spinal cord More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding zinc ion binding protein binding metal ion binding nucleic acid binding translation elongation factor activity Cellular component transcription elongation factor complex nucleus Biological process DNA-templated transcription, elongation regulation of transcription, DNA-templated transcription, DNA-templated positive regulation of transcription by RNA polymerase II regulation of DNA-templated transcription, elongation translational elongation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6919 21400 Ensembl ENSG00000171703 ENSMUSG00000059540 UniProt Q15560 Q6IB64 Q9QVN7 RefSeq (mRNA) NM_003195 NM_198723 NM_009326 NM_001356342 NM_001356343 RefSeq (protein) NP_003186 NP_942016 NP_003186.1 NP_033352 NP_001343271 NP_001343272 Location (UCSC) Chr 20: 64.05 – 64.07 Mb Chr 2: 181.32 – 181.33 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene is found in the nucleus, where it functions as an SII class transcription elongation factor. Elongation factors in this class are responsible for releasing RNA polymerase II ternary complexes from transcriptional arrest at template-encoded arresting sites. The encoded protein has been shown to interact with general transcription factor IIB, a basal transcription factor. Two transcript variants encoding different isoforms have been found for this gene.^[7]

Interactions

TCEA2 has been shown to interact with MAGEA11.^[8]