TCEAL1

Transcription elongation factor A protein-like 1 is a protein that in humans is encoded by the TCEAL1 gene.^[5][6][7]

TCEAL1
Identifiers
Aliases	TCEAL1, SIIR, WEX9, p21, pp21, transcription elongation factor A like 1
External IDs	OMIM: 300237; MGI: 2385317; HomoloGene: 3510; GeneCards: TCEAL1; OMA:TCEAL1 - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xq22.2 Start 103,628,704 bp[1] End 103,630,953 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X|X F1 Start 135,608,731 bp[2] End 135,612,227 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right ovary left ovary left uterine tube body of uterus gastric mucosa right coronary artery canal of the cervix thoracic aorta Descending thoracic aorta ascending aorta Top expressed in dorsomedial hypothalamic nucleus facial motor nucleus mammillary body arcuate nucleus paraventricular nucleus of hypothalamus median eminence ventromedial nucleus Region I of hippocampus proper barrel cortex lateral hypothalamus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity WW domain binding Cellular component nucleus nucleoplasm Biological process regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9338 237052 Ensembl ENSG00000172465 ENSMUSG00000049536 UniProt Q15170 Q921P9 RefSeq (mRNA) NM_004780 NM_001006639 NM_001006640 NM_146236 NM_001356367 RefSeq (protein) NP_001006640 NP_001006641 NP_004771 NP_666348 NP_001343296 Location (UCSC) Chr X: 103.63 – 103.63 Mb Chr X: 135.61 – 135.61 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a member of the transcription elongation factor A (SII)-like (TCEAL) gene family. Members of this family may function as nuclear phosphoproteins that modulate transcription in a promoter context-dependent manner. The encoded protein is similar to transcription elongation factor A/transcription factor SII and contains a zinc finger-like motif as well as a sequence related to the transcription factor SII Pol II-binding region. It may exert its effects via protein-protein interactions with other transcriptional regulators rather than via direct binding of DNA. Multiple family members are located on the X chromosome. Alternative splicing results in multiple transcript variants encoding a single isoform.^[7]