ELOC

Elongin C is a protein that in humans is encoded by the ELOC gene.^[5][6]

ELOC
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1LM8, 1LQB, 1VCB, 2C9W, 2IZV, 2MA9, 3DCG, 3ZKJ, 3ZNG, 3ZRC, 3ZRF, 3ZTC, 3ZTD, 3ZUN, 4AJY, 4AWJ, 4B95, 4B9K, 4BKS, 4BKT, 4N9F, 4W9C, 4W9D, 4W9E, 4W9F, 4W9G, 4W9H, 4W9I, 4W9J, 4W9K, 4W9L, 4WQO, 5BO4
Identifiers
Aliases	ELOC, SIII, eloC, TCEB1, transcription elongation factor B subunit 1, elongin C
External IDs	OMIM: 600788; MGI: 1915173; HomoloGene: 38083; GeneCards: ELOC; OMA:ELOC - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q21.11 Start 73,939,169 bp[1] End 73,972,307 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 A3 Start 16,711,949 bp[2] End 16,727,266 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte sperm right ventricle gingival epithelium palpebral conjunctiva left testis right testis tendon of biceps brachii biceps brachii amniotic fluid Top expressed in morula primary oocyte blastocyst primitive streak endothelial cell of lymphatic vessel epithelium of stomach yolk sac facial motor nucleus medial ganglionic eminence atrioventricular valve More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding ubiquitin-protein transferase activity Cellular component cytosol nucleus elongin complex nucleoplasm Biological process regulation of transcription by RNA polymerase II transcription elongation from RNA polymerase II promoter regulation of transcription, DNA-templated transcription by RNA polymerase II ubiquitin-dependent protein catabolic process transcription, DNA-templated regulation of transcription from RNA polymerase II promoter in response to hypoxia viral process positive regulation of transcription elongation from RNA polymerase II promoter post-translational protein modification protein ubiquitination Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6921 67923 Ensembl ENSG00000154582 ENSMUSG00000079658 UniProt Q15369 P83940 RefSeq (mRNA) NM_001204857 NM_001204858 NM_001204859 NM_001204860 NM_001204861 NM_001204862 NM_001204863 NM_001204864 NM_005648 NM_001310470 NM_026456 RefSeq (protein) NP_001191786 NP_001191787 NP_001191788 NP_001191789 NP_001191790 NP_001191791 NP_001191792 NP_001191793 NP_005639 NP_001297399 NP_080732 Location (UCSC) Chr 8: 73.94 – 73.97 Mb Chr 1: 16.71 – 16.73 Mb PubMed search [3] [4]
Wikidata
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Function

Elongin C is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation.^[7]

Interactions

TCEB1 has been shown to interact with:

• TCEB2^{[8][9][10][11]} and
• Von Hippel-Lindau tumor suppressor.^{[9][11][12][13][14][15][16]}