ELOB

Elongin B is a protein that in humans is encoded by the ELOB gene.^[3]

ELOB
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1LM8, 1LQB, 1VCB, 2C9W, 2IZV, 2JZ3, 2MA9, 3DCG, 3ZKJ, 3ZNG, 3ZRC, 3ZRF, 3ZTC, 3ZTD, 3ZUN, 4AJY, 4AWJ, 4B95, 4B9K, 4BKS, 4BKT, 4N9F, 4W9C, 4W9D, 4W9E, 4W9F, 4W9G, 4W9H, 4W9I, 4W9J, 4W9K, 4W9L, 4WQO, 5BO4
Identifiers
Aliases	ELOB, SIII, TCEB2, transcription elongation factor B subunit 2, elongin B
External IDs	OMIM: 600787; HomoloGene: 134544; GeneCards: ELOB; OMA:ELOB - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p13.3 Start 2,771,414 bp[1] End 2,777,289 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left testis right testis apex of heart muscle of thigh stromal cell of endometrium anterior pituitary nucleus accumbens olfactory zone of nasal mucosa prefrontal cortex ganglionic eminence n/a More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding ubiquitin protein ligase binding Cellular component Cul2-RING ubiquitin ligase complex cytosol Cul5-RING ubiquitin ligase complex VCB complex nucleus elongin complex nucleoplasm Biological process transcription elongation from RNA polymerase II promoter regulation of transcription, DNA-templated transcription by RNA polymerase II transcription, DNA-templated regulation of transcription from RNA polymerase II promoter in response to hypoxia protein ubiquitination post-translational protein modification protein-containing complex assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6923 n/a Ensembl ENSG00000103363 n/a UniProt Q15370 n/a RefSeq (mRNA) NM_207013 NM_007108 n/a RefSeq (protein) NP_009039 NP_996896 n/a Location (UCSC) Chr 16: 2.77 – 2.78 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Function

Elongin B is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.^[4]

Interactions

TCEB2 has been shown to interact with:

• CUL2,^[5][6]
• TCEB1,^{[7][8][9][10]} and
• Von Hippel-Lindau tumor suppressor.^{[5][8][11][12][13]}