Transcription elongation regulator 1

Transcription elongation regulator 1, also known as TCERG1, is a protein which in humans is encoded by the TCERG1 gene.^[5][6][7]

TCERG1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DK7, 2DOD, 2DOE, 2DOF, 2E71, 2KIQ, 2KIS, 2MW9, 2MWA, 2MWB, 2MWD, 2MWF, 2NNT, 3HFH, 3Q1I, 4FQG, 2N4R, 2N4S, 2N4T, 2N4U, 2N4V, 2N4W
Identifiers
Aliases	TCERG1, CA150, TAF2S, Urn1, transcription elongation regulator 1
External IDs	OMIM: 605409; MGI: 1926421; HomoloGene: 4879; GeneCards: TCERG1; OMA:TCERG1 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q32 Start 146,447,311 bp[1] End 146,511,961 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 B3 Start 42,644,552 bp[2] End 42,708,858 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum right uterine tube sural nerve ventricular zone Achilles tendon ganglionic eminence left ovary right ovary anterior pituitary skin of abdomen Top expressed in tail of embryo genital tubercle zygote ventricular zone neural layer of retina yolk sac secondary oocyte embryo embryo dentate gyrus of hippocampal formation granule cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transcription coactivator activity transcription corepressor activity proline-rich region binding protein binding RNA binding identical protein binding RNA polymerase binding Cellular component nucleus nucleoplasm Biological process regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II transcription by RNA polymerase II transcription, DNA-templated positive regulation of nucleic acid-templated transcription Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10915 56070 Ensembl ENSG00000113649 ENSMUSG00000024498 UniProt O14776 Q8CGF7 RefSeq (mRNA) NM_001040006 NM_006706 NM_001382548 NM_001039474 NM_001289526 NM_001360881 NM_019512 RefSeq (protein) NP_001035095 NP_006697 NP_001369477 NP_001034563 NP_001276455 NP_001347810 Location (UCSC) Chr 5: 146.45 – 146.51 Mb Chr 18: 42.64 – 42.71 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a nuclear protein that regulates transcriptional elongation and pre-mRNA splicing. The encoded protein interacts with the hyperphosphorylated C-terminal domain of RNA polymerase II via multiple FF domains, and with the pre-mRNA splicing factor SF1 via a WW domain. Alternative splicing results in multiple transcripts variants encoding different isoforms.^[5]

Interactions

Transcription elongation regulator 1 has been shown to interact with SF1^[8] and POLR2A.^[9]