TCF7

For the TCF1 gene, see HNF1A.

Transcription factor 7 is the gene that in humans encodes for the TCF1 protein.^[5]

TCF7
Identifiers
Aliases	TCF7, TCF-1, transcription factor 7 (T-cell specific, HMG-box), transcription factor 7
External IDs	OMIM: 189908; MGI: 98507; HomoloGene: 135816; GeneCards: TCF7; OMA:TCF7 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q31.1 Start 134,114,681 bp[1] End 134,151,865 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 B1.3|11 31.86 cM Start 52,252,371 bp[2] End 52,283,014 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in thymus periodontal fiber lymph node right uterine tube granulocyte cecum appendix blood cardia buccal mucosa cell Top expressed in thymus mesenteric lymph nodes tail of embryo zygote blood labioscrotal swelling secondary oocyte molar epiblast spleen More reference expression data BioGPS More reference expression data
Gene ontology Molecular function sequence-specific DNA binding DNA binding DNA-binding transcription factor activity protein binding DNA-binding transcription repressor activity, RNA polymerase II-specific beta-catenin binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component transcription regulator complex nucleus nucleoplasm nuclear body Biological process cellular response to interleukin-4 regulation of transcription, DNA-templated T cell receptor V(D)J recombination negative regulation of transcription by RNA polymerase II embryonic hindgut morphogenesis Wnt signaling pathway transcription, DNA-templated canonical Wnt signaling pathway involved in negative regulation of apoptotic process embryonic genitalia morphogenesis regulation of cell population proliferation immune response neural tube development embryonic digestive tract morphogenesis alpha-beta T cell differentiation beta-catenin-TCF complex assembly regulation of transcription by RNA polymerase II canonical Wnt signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6932 21414 Ensembl ENSG00000081059 ENSMUSG00000000782 UniProt P36402 Q00417 RefSeq (mRNA) NM_001134851 NM_001134852 NM_003202 NM_201632 NM_201634 NM_213648 NM_001346425 NM_001346450 NM_001366502 NM_009331 NM_001313981 RefSeq (protein) NP_001128323 NP_001333354 NP_001333379 NP_003193 NP_963963 NP_963965 NP_998813 NP_001353431 NP_001300910 NP_033357 Location (UCSC) Chr 5: 134.11 – 134.15 Mb Chr 11: 52.25 – 52.28 Mb PubMed search [3] [4]
Wikidata
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