TCIM

TCIM is a protein that in humans is encoded by the TCIM gene.^[5][6]

TCIM
Identifiers
Aliases	TCIM, TC-1, TC1, C8orf4, chromosome 8 open reading frame 4, transcriptional and immune response regulator
External IDs	OMIM: 607702; MGI: 1916318; HomoloGene: 10590; GeneCards: TCIM; OMA:TCIM - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8p11.21 Start 40,153,482 bp[1] End 40,155,310 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 A2 Start 24,927,196 bp[2] End 24,929,000 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in parotid gland gallbladder right lung vena cava mucosa of urinary bladder seminal vesicula upper lobe of left lung pericardium visceral pleura rectum Top expressed in parotid gland lacrimal gland left lung lobe interventricular septum seminal vesicula molar olfactory epithelium epithelium of small intestine intestinal villus brown adipose tissue More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Notch binding Cellular component cytoplasm nuclear speck nucleolus nucleus nucleoplasm cytosol plasma membrane intracellular anatomical structure Biological process regulation of cell cycle G1/S phase transition endothelial cell activation involved in immune response cellular response to heat regulation of DNA-templated transcription in response to stress regulation of hemopoiesis negative regulation of Notch signaling pathway apoptotic process positive regulation of protein kinase A signaling negative regulation of apoptotic process positive regulation of protein kinase C activity positive regulation of NIK/NF-kappaB signaling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 56892 69068 Ensembl ENSG00000176907 ENSMUSG00000056313 UniProt Q9NR00 Q9D915 RefSeq (mRNA) NM_020130 NM_026931 RefSeq (protein) NP_064515 NP_081207 Location (UCSC) Chr 8: 40.15 – 40.16 Mb Chr 8: 24.93 – 24.93 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a small, monomeric, predominantly unstructured protein (106 amino acids, 12.3 kDa, isoelectric point 9.39).^[7] It is a positive regulator of the Wnt / beta-catenin signaling pathway. This protein interacts with a repressor of beta-catenin mediated transcription at nuclear speckles. It is thought to competitively block interactions of the repressor with beta-catenin, resulting in up-regulation of beta-catenin target genes.^[6]