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T-complex 1

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

T-complex 1
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T-complex protein 1 or T-complex protein 1 subunit alpha, abbreviated TCP1 or TCP-1,[a] is a protein that in humans is encoded by the TCP1 gene.[5][6][7]

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Function

This protein is a member of TRiC (CCT) complex, which is a molecular chaperone and the chaperonin of eukaryotic cells. This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized.[7]

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Interactions

TCP1 has been shown to interact with PPP4C[8][9] and HDAC3.[10] TRiC directly interacts with lectin type oxidized LDL receptor-1 (LOX-1) while its ligand oxidized low density lipoprotein (OxLDL) disassociates TRiC from LOX-1.[11]

Notes

  1. The term "TCP-1" is variously expanded as "T-complex protein 1" and "tailless complex polypeptide 1". The "T-complex" is the same as tailless complex, a CCT locus associated with tail length in mice.

References

Further reading

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