PPP4C

Serine/threonine-protein phosphatase 4 catalytic subunit is an enzyme that in humans is encoded by the PPP4C gene.^[5][6]

PPP4C
Identifiers
Aliases	PPP4C, PP4, PP4C, PPH3, PPP4, PPX, PP-X, protein phosphatase 4 catalytic subunit
External IDs	OMIM: 602035; MGI: 1891763; HomoloGene: 2038; GeneCards: PPP4C; OMA:PPP4C - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p11.2 Start 30,075,978 bp[1] End 30,085,376 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 F3 Start 126,385,038 bp[2] End 126,391,668 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte granulocyte stromal cell of endometrium mucosa of transverse colon right testis left testis skin of abdomen skin of leg ganglionic eminence left adrenal gland Top expressed in mandibular prominence maxillary prominence granulocyte epiblast somite abdominal wall primitive streak thymus ventricular zone medial ganglionic eminence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phosphoprotein phosphatase activity metal ion binding NF-kappaB-inducing kinase activity protein binding hydrolase activity protein serine/threonine phosphatase activity Cellular component plasma membrane nucleoplasm microtubule organizing center cytoskeleton nucleus protein phosphatase 4 complex cytoplasm cytosol Biological process regulation of double-strand break repair via homologous recombination NIK/NF-kappaB signaling protein dephosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5531 56420 Ensembl ENSG00000149923 ENSMUSG00000030697 UniProt P60510 P97470 RefSeq (mRNA) NM_001303503 NM_001303504 NM_001303506 NM_001303507 NM_002720 NM_019674 NM_001360464 RefSeq (protein) NP_001290432 NP_001290433 NP_001290435 NP_001290436 NP_002711 NP_062648 NP_001347393 Location (UCSC) Chr 16: 30.08 – 30.09 Mb Chr 7: 126.39 – 126.39 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

PPP4C has been shown to interact with:

• CCDC6,^[7][8]
• CCT2,^[7][9]
• CCT3,^[7][9]
• CCT4,^[7][9]
• CCT5,^[7][9]
• CCT6A,^[7][9]
• CCT7,^[7][9]
• IGBP1,^[7][9][10]
• PPP2R1A,^[7][8]
• PPP4R1,^[7][8][9]
• REL,^[11]
• SMEK2,^[7][8][9]
• T-complex 1,^[7][9] and
• TRAF6.^[12]