TEAD3

Transcriptional enhancer factor TEF-5 is a protein that in humans is encoded by the TEAD3 gene.^[5][6][7]

TEAD3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5EMW
Identifiers
Aliases	TEAD3, DTEF-1, ETFR-1, TEAD-3, TEAD5, TEF-5, TEF5, TEA domain transcription factor 3
External IDs	OMIM: 603170; MGI: 109241; HomoloGene: 81821; GeneCards: TEAD3; OMA:TEAD3 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p21.31 Start 35,473,597 bp[1] End 35,497,079 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17 A3.3|17 14.66 cM Start 28,550,645 bp[2] End 28,569,791 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in muscle layer of sigmoid colon gastric mucosa body of uterus left uterine tube popliteal artery tibial arteries right coronary artery thoracic aorta ascending aorta ectocervix Top expressed in lip genital tubercle esophagus trophoblast giant cell ventricular zone muscle of thigh neural layer of retina urethra female urethra molar More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity DNA binding protein binding sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleoplasm nucleus transcription regulator complex Biological process regulation of transcription by RNA polymerase II female pregnancy transcription initiation from RNA polymerase II promoter regulation of transcription, DNA-templated hippo signaling transcription, DNA-templated asymmetric neuroblast division positive regulation of transcription by RNA polymerase II embryonic organ development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7005 21678 Ensembl ENSG00000007866 ENSMUSG00000002249 UniProt Q99594 P70210 RefSeq (mRNA) NM_003214 NM_001395214 NM_001098226 NM_001204156 NM_011566 RefSeq (protein) NP_003205 NP_001091696 NP_001191085 NP_035696 Location (UCSC) Chr 6: 35.47 – 35.5 Mb Chr 17: 28.55 – 28.57 Mb PubMed search [3] [4]
Wikidata
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Function

This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain.^[8] Members of the family in mammals are TEAD1, TEAD2, TEAD3, TEAD4. Transcriptional coregulators, such as WWTR1 (TAZ) bind to these transcription factors. TEAD3 is predominantly expressed in the placenta and is involved in the transactivation of the chorionic somatomammotropin-B gene enhancer. It is expressed in nervous system and muscle in fish embryos.^[9] Translation of this protein is initiated at a non-AUG (AUA) start codon.^[7]