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TECR

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

TECR
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Trans-2,3-enoyl-CoA reductase is an enzyme that in humans is encoded by the TECR gene.[5]

Quick Facts Available structures, PDB ...
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This gene encodes a multi-pass membrane protein that resides in the endoplasmic reticulum, and belongs to the steroid 5-alpha reductase family. The elongation of microsomal long and very long chain fatty acid consists of 4 sequential reactions. This protein catalyzes the final step, reducing trans-2,3-enoyl-CoA to saturated acyl-CoA. Alternatively spliced transcript variants have been found for this gene.[5]

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Clinical relevance

Mutations in this gene have been shown to cause non-syndromic mental retardation.[6]

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