TELO2

Telomere length regulation protein TEL2 homolog is a protein that in humans is encoded by the TELO2 gene.^[5][6][7][8]

TELO2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4PSI
Identifiers
Aliases	TELO2, CLK2, TEL2, telomere maintenance 2, YHFS
External IDs	OMIM: 611140; MGI: 1918968; HomoloGene: 41107; GeneCards: TELO2; OMA:TELO2 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p13.3 Start 1,493,344 bp[1] End 1,510,457 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 A3.3 Start 25,318,544 bp[2] End 25,334,941 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube right hemisphere of cerebellum apex of heart granulocyte right lobe of liver gastric mucosa mucosa of transverse colon spleen canal of the cervix anterior pituitary Top expressed in molar inferior colliculi paraventricular nucleus of hypothalamus olfactory tubercle globus pallidus external carotid artery deep cerebellar nuclei medial geniculate nucleus subiculum anterior amygdaloid area More reference expression data BioGPS More reference expression data
Gene ontology Molecular function molecular adaptor activity Hsp90 protein binding protein binding protein kinase binding protein-containing complex binding telomeric DNA binding Cellular component cytoplasm telomere TORC1 complex TORC2 complex intracellular anatomical structure membrane nuclear periphery nucleus chromosome cytosol nuclear body ASTRA complex Biological process positive regulation of TORC1 signaling protein stabilization regulation of TOR signaling positive regulation of TORC2 signaling positive regulation of protein serine/threonine kinase activity telomere maintenance Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9894 71718 Ensembl ENSG00000100726 ENSMUSG00000024170 UniProt Q9Y4R8 Q9DC40 RefSeq (mRNA) NM_016111 NM_001351846 NM_001163661 NM_027880 RefSeq (protein) NP_057195 NP_001338775 NP_001157133 NP_082156 Location (UCSC) Chr 16: 1.49 – 1.51 Mb Chr 17: 25.32 – 25.33 Mb PubMed search [3] [4]
Wikidata
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Function

In 2007, researchers reported an unexpected role for Tel2 in the expression of all mammalian phosphatidylinositol 3-kinase-related protein kinases (PIKKs). Although Tel2 was identified as a budding yeast gene required for the telomere length maintenance, they found no obvious telomeric function for mammalian Tel2. Tel2 deletion also curbed mTOR signaling, indicating that Tel2 affects mammalian PIKKs. Tel2 binds to part of the HEAT repeat segments of ATM and mTOR and is a highly conserved regulator of PIKK stability.^[9]