TEP1

Telomerase protein component 1 is an enzyme that in humans is encoded by the TEP1 gene.^[5][6]

TEP1
Identifiers
Aliases	TEP1, TLP1, TP1, TROVE1, VAULT2, p240, telomerase associated protein 1
External IDs	OMIM: 601686; MGI: 109573; HomoloGene: 5157; GeneCards: TEP1; OMA:TEP1 - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q11.2 Start 20,365,667 bp[1] End 20,413,501 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14 C1|14 26.26 cM Start 51,061,516 bp[2] End 51,108,017 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte mucosa of transverse colon jejunal mucosa epithelium of colon rectum granulocyte duodenum spleen lymph node tonsil Top expressed in duodenum intestinal villus Ileal epithelium jejunum large intestine colon crypt of lieberkuhn of small intestine stroma of bone marrow Paneth cell lumbar spinal ganglion More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ATP binding p53 binding nucleotide binding enzyme binding telomerase RNA binding telomerase activity RNA binding Cellular component telomere telomerase holoenzyme complex nucleus cytoplasm nuclear matrix chromosome U5 snRNP precatalytic spliceosome catalytic step 2 spliceosome ribonucleoprotein complex Biological process telomere maintenance via recombination RNA-dependent DNA biosynthetic process RNA splicing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7011 21745 Ensembl ENSG00000129566 ENSMUSG00000006281 UniProt Q99973 P97499 RefSeq (mRNA) NM_007110 NM_001319035 NM_009351 RefSeq (protein) NP_001305964 NP_009041 NP_033377 Location (UCSC) Chr 14: 20.37 – 20.41 Mb Chr 14: 51.06 – 51.11 Mb PubMed search [3] [4]
Wikidata
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Function

This gene product is a component of the ribonucleoprotein complex responsible for telomerase activity which catalyzes the addition of new telomeres on the chromosome ends. The telomerase-associated proteins are conserved from ciliates to humans.^[6] It is also a minor vault protein.