TERF2IP

Telomeric repeat-binding factor 2-interacting protein 1 also known as repressor activator protein 1 (Rap1) is a protein that in humans is encoded by the TERF2IP gene.^[5][6]

TERF2IP
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1FEX, 3K6G, 4RQI
Identifiers
Aliases	TERF2IP, DRIP5, RAP1, TERF2 interacting protein
External IDs	OMIM: 605061; MGI: 1929871; HomoloGene: 10357; GeneCards: TERF2IP; OMA:TERF2IP - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16q23.1 Start 75,647,773 bp[1] End 75,761,872 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 E1 Start 112,738,030 bp[2] End 112,747,160 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in middle temporal gyrus Brodmann area 23 pars compacta pars reticulata superior vestibular nucleus pons internal globus pallidus lateral nuclear group of thalamus Brodmann area 9 superior frontal gyrus Top expressed in ventromedial nucleus supraoptic nucleus paraventricular nucleus of hypothalamus dorsomedial hypothalamic nucleus lateral hypothalamus lumbar subsegment of spinal cord ventral tegmental area arcuate nucleus dorsal tegmental nucleus mammillary body More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding telomeric DNA binding protein binding G-rich strand telomeric DNA binding phosphatase binding Cellular component nuclear telomere cap complex nuclear envelope chromosome shelterin complex telomere nuclear chromosome Mre11 complex nucleus nucleoplasm cytosol nuclear body cytoplasm Biological process negative regulation of DNA recombination at telomere telomere maintenance via telomerase protection from non-homologous end joining at telomere regulation of double-strand break repair via homologous recombination transcription, DNA-templated positive regulation of peptidyl-serine phosphorylation protein localization to chromosome, telomeric region positive regulation of protein acetylation telomere maintenance via telomere lengthening positive regulation of NF-kappaB transcription factor activity positive regulation of I-kappaB kinase/NF-kappaB signaling telomere maintenance telomere capping negative regulation of protein phosphorylation regulation of transcription, DNA-templated regulation of telomere maintenance negative regulation of telomere maintenance positive regulation of NIK/NF-kappaB signaling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54386 57321 Ensembl ENSG00000166848 ENSMUSG00000033430 UniProt Q9NYB0 Q91VL8 RefSeq (mRNA) NM_018975 NM_020584 RefSeq (protein) NP_061848 NP_065609 Location (UCSC) Chr 16: 75.65 – 75.76 Mb Chr 8: 112.74 – 112.75 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Not to be confused with Rap1.

Interactions

TERF2IP has been shown to interact with Ku80,^[7] Rad50^[7] and TERF2.^[5][7][8] Upon interaction, TERF2IP/TERF2 complex has been shown to bind to telomeric junction sites with higher affinity^[9]